| Title: | Investigation of the association between air pollutants and the long-term risk of sudden cardiac death |
| Journal: | Chinese Journal of Emergency Medicine |
| Published: | 10 Jun 2025 |
| DOI: | https://doi.org/10.3760/cma.j.issn.1671-0282.2025.06.016 |
Publication 16262
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Abstract
Objective The association between air pollutants and the risk of sudden cardiac death (SCD) remains controversial. This study aimed to investigate the relationship between five air pollutants - PM 2.5 , PM 2.5-10 , PM 10 , NO 2 , and NOₓ - and the risk of SCD. Methods We analyzed data from 460 862 participants in the UK Biobank cohort, all enrolled between 2006 and 2010, with no baseline SCD. Follow-up continued until the study endpoint. Annual average concentrations of the five pollutants were assessed. Associations between pollutants and SCD were evaluated using Cox proportional hazards models, followed by Mendelian randomization (MR) to assess causality. Results Over a mean follow-up of 12.4 years, 2 662 SCD cases were recorded. After adjusting for confounders, no significant associations were found between air pollutants and SCD risk: PM 2.5 ( HR 1.03, 95% CI 0.99-1.07, P = 0.14), PM 2.5-10 ( HR 1.04, 95% CI 1.00-1.08, P = 0.08), PM 10 ( HR 1.01, 95% CI 0.99-1.03, P = 0.26), NOₓ ( HR 1.00, 95% CI 0.99-1.00, P = 0.26), and NO x ( HR 1.00, 95% CI 1.00-1.01, P = 0.19). MR analysis further supported the absence of causal relationships: PM 2.5 ( β = -0.149, P = 0.90), PM 2.5-10 ( β = 0.387, P = 0.62), PM 10 ( β = -0.994, P = 0.62), NOₓ ( β = -0.005, P = 0.99), and NO 2 ( β = -0.827, P = 0.25). Conclusions This study found no evidence linking PM 2.5 , PM 2.5-10 , PM 10 , NOₓ, or NO 2 to an increased risk of SCD. Mendelian randomization confirmed the lack of causal associations between these pollutants and SCD.</p>
8 Authors
- 潘月
- 王水
- 蒋林惠
- 李梦雅
- 王一帆
- 戴俊程
- 陈旭锋
- 张刚
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