| Title: | Association of oxidative balance score with incident cardiovascular disease in patients with type 2 diabetes: findings of the UK Biobank study |
| Journal: | European Journal of Nutrition |
| Published: | 6 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40047957/ |
| DOI: | https://doi.org/10.1007/s00394-024-03552-2 |
Publication 16211
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Abstract
Background & aimsTo clarify how dietary and lifestyle factors work on diabetes-related cardiovascular disease (CVD), we investigated whether the increased risk of CVD in patients with type 2 diabetes mellitus (T2DM) could be offset by an increase in diet and/or lifestyle with antioxidant potential.Research design and methodsA total of 7,658 individuals from UK Biobank (UKB) with T2DM but no diagnosed CVD were included in this study. We screened combinations of 16 nutrients and/or 4 lifestyles to calculate the Oxidative Balance Score (OBS), dietary OBS (DOBS), and lifestyle OBS (LOBS). Cox proportional hazards (CPH) regression models and mediation statistical models were performed.ResultsAfter adjusting for covariates, CPH regression models showed inverse associations between both OBS and LOBS and CVD. The highest tertile of LOBS was significantly associated with a lower risk of CVD compared to the lowest tertile, with hazard ratios and 95% CIs as follows: Atherosclerotic Cardiovascular Disease (ASCVD) 0.81 (0.68-0.97), Coronary Artery Disease (CAD) 0.79 (0.67-0.93), Atrial Fibrillation (AF) 0.56 (0.45-0.70) and CVD mortality 0.67(0.51-0.88). Correspondingly, the results of associations between the highest tertile of OBS and risks of CVDs above were ASCVD 0.80 (0.64-0.99), CAD 0.83(0.68-1.01), AF 0.73 (0.57-0.92) and CVD mortality 0.68 (0.50-0.92). No associations between DOBS and CVDs were observed [ASCVD 0.83 (0.66-1.05), CAD 0.86 (0.70-1.05), AF 0.77 (0.60-1.00), and CVD mortality 0.79 (0.57-1.10)]. These results were consistent in stratified analyses. Additionally, we identified a mediating role for C-reactive protein (CRP) and white blood cell count (WBC) in the observed relations, with indirect effect and mediation estimates as follows: CRP − 0.003 6.0% (OBS and CAD), -0.008 17.2%, -0.003 11.7%, and − 0.010 14.5% (OBS/DOBS/LOBS and CVD mortality); WBC − 0.006 14.3%, -0.006 12.6%, -0.006 13.4%, -0.005 23.3% (OBS and CVDs), -0.008 11.8%, -0.008 11.9%, -0.008 11.8%, and − 0.005 5.3% (LOBS and CVDs).ConclusionSustained adherence to diets and lifestyles with high antioxidant potential may significantly reduce the risk of CVD in individuals with T2DM.</p>
17 Keywords
- Aged
- Antioxidants
- Biological Specimen Banks
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Diet
- Female
- Humans
- Incidence
- Life Style
- Male
- Middle Aged
- Oxidative Stress
- Proportional Hazards Models
- Risk Factors
- UK Biobank
- United Kingdom
9 Authors
- Licheng Cheng
- Xuanyang Wang
- Keke Dang
- Jinxia Hu
- Jia Zhang
- Xiaoqing Xu
- Sijia Pan
- Xiang Qi
- Ying Li
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