| Title: | Association of pulmonary function with the risk of incident Alzheimer's disease: a prospective cohort and Mendelian randomization study |
| Journal: | Aging Clinical and Experimental Research |
| Published: | 1 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40802026/ |
| DOI: | https://doi.org/10.1007/s40520-025-03151-z |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/12350532 |
Publication 16206
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Abstract
IntroductionThe causal association between pulmonary function and Alzheimer's disease (AD) remains unclear. This study aimed to investigate whether low pulmonary function has a causal relationship with the risk of AD.MethodsWe conducted prospective cohort and two-sample Mendelian randomization (MR) studies. In the cohort study, 333,816 UK Biobank participants were eligible for analysis. Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, percentage of predicted normal value of FEV1 (FEV1% pred), and peak expiratory flow (PEF) were measured at baseline. Longitudinal associations were investigated using cox-proportional hazard models. We conducted univariate and multivariable MR analyses on genome-wide association study (GWAS) data from 421,986 Europeans for FEV1, FVC, and PEF. Inverse-variance weighting was employed as the primary MR analysis approach.ResultsOver a median follow-up of 12.8 years (10.3-15.0 years), 2275 incident cases of AD were identified in the cohort study. Compared to the highest quartile, the lowest quartile for pulmonary function exhibited a higher risk of incident AD, and hazard ratios (95% CI) were as follows after adjustment for risk factors: 1.81 (1.32-2.48; FEV1), 1.97 (1.44-2.69; FVC), and 1.86 (1.39-2.47; PEF). In the MR study, genetically determined high FEV1 was associated with a decreased risk of AD (odds ratio: 0.68, 95% CI: 0.53-0.88). The results remained robust after sensitivity and multivariable MR analyses.ConclusionOur findings suggest the potential causal association between high FEV1 and decreased risk of AD.</p>
6 Authors
- Ya-Nan Zheng
- Peng Qiu
- Hui-Huan Luo
- Ren-Jie Chen
- Xue-Qiang Wang
- Pei-Jie Chen
1 Application
| Application ID | Title |
|---|---|
| 92476 | Associations of chronic diseases with physical activity, muscle strength, lung function and cognitive function |
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