| Title: | Breastfeeding, genetic susceptibility, and type 2 diabetes in offspring in later life |
| Journal: | Obesity |
| Published: | 23 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40702764/ |
| DOI: | https://doi.org/10.1002/oby.24344 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.24344 |
Publication 16113
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Abstract
OBJECTIVE: Our objective was to assess the prospective association between breastfeeding and the risk of type 2 diabetes (T2D) in offspring and to investigate the joint effects of breastfeeding and genetic susceptibility on T2D risk.</p>
METHODS: We included 364,562 participants free from prevalent T2D from the UK Biobank. Cox proportional hazards models were employed to evaluate the association between breastfeeding and incident T2D.</p>
RESULTS: Over a median follow-up of 12 years, 12,795 cases of incident T2D were recorded. Ever breastfeeding was associated with a significantly lower risk of T2D compared with never breastfeeding (hazard ratio = 0.94, 95% CI: 0.89-0.99). Additionally, significant interaction effects on T2D risk were observed between breastfeeding and T2D genetic risk score (T2D-GRS), both multiplicatively and additively. The association between T2D-GRS and risk of T2D was stronger in participants who were never breastfed compared with those who were breastfed (p for multiplicative interaction = 0.040). The risk of T2D associated with never breastfeeding combined with a high T2D-GRS was greater than the sum of the risks associated with each individual factor (p for additive interaction = 0.007).</p>
CONCLUSIONS: Breastfeeding is associated with a lower risk of incident T2D in offspring, showing both multiplicative and additive interactions with T2D-GRS.</p>
6 Authors
- Ying Hu
- Hao Ma
- Xuan Wang
- Shuqi Zhu
- Danqing Chen
- Zhaoxia Liang
1 Application
| Application ID | Title |
|---|---|
| 122673 | The effect of metabolic disease during pregnancy on long-term cardiovascular health |
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