| Title: | Association of sugar intake with incident dementia in the UK Biobank: a prospective cohort study |
| Journal: | The Journal of Prevention of Alzheimer's Disease |
| Published: | 5 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40750513/ |
| DOI: | https://doi.org/10.1016/j.tjpad.2025.100311 |
Publication 16072
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Abstract
BACKGROUND: Excessive sugar intake has been implicated in increased dementia risk; however, existing studies are constrained by small sample sizes and a primary focus on total sugar, with limited investigation into specific sugar subtypes. This study explores the relationship between sugar intake, its subtypes, and the incidence of dementia.</p>
METHODS: We analyzed 172,516 participants from the UK Biobank who completed at least one 24-hour dietary recall (Oxford WebQ). Cox proportional hazards models estimated the hazard ratios (HRs) and 95 % confidence intervals (95 % CIs) for total sugar and its subtypes (free sugar, fructose, glucose, sucrose, maltose, lactose, and other sugars) about the risk of dementia. Sex-stratified analyses were also performed.</p>
RESULTS: Higher intakes of total sugar (HR = 1.292, 95 % CI = 1.148--1.453) and free sugar intake (HR = 1.254, 95 % CI = 1.117--1.408) were significantly associated with increased dementia risk. Positive associations were also observed for non-milk extrinsic sugars (HR = 1.321, 95 % CI = 1.175--1.486) and sucrose (HR = 1.291, 95 % CI = 1.147--1.452). These associations were evident in women, with higher intakes of total sugars, free sugars, glucose, sucrose, and non-milk extrinsic sugars independently linked to increased dementia risk, whereas no significant associations were found in men.</p>
CONCLUSION: Higher consumption of total sugars, free sugars, sucrose, and non-milk extrinsic sugars confers increased dementia risk, particularly among women.</p>
14 Keywords
- Aged
- Biological Specimen Banks
- Dementia
- Dietary Sugars
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- UK Biobank
- United Kingdom
14 Authors
- Yue Che
- Wenming Wei
- Tingting Mao
- Lina Qin
- Hanchi Wang
- Yijia Li
- Weixuan Da
- Jin Feng
- Li Liu
- Bolun Cheng
- Huan Liu
- Yan Wen
- Yumeng Jia
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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