| Title: | Health risks and genetic architecture of objectively measured multidimensional sleep health |
| Journal: | Nature Communications |
| Published: | 31 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40745165/ |
| DOI: | https://doi.org/10.1038/s41467-025-62338-0 |
| URL: | https://www.nature.com/articles/s41467-025-62338-0.pdf |
Publication 16070
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Abstract
A multidimensional sleep health framework improves screening and treatment efficacy by simultaneously addressing multiple sleep domains. However, limited studies have used objective measures to evaluate the co-occurrence of diverse unhealthy sleep characteristics and their pleiotropic health effects. To represent real-world sleep patterns, we introduce the Unfavorable Sleep Profile (USP), an integrated multidimensional sleep health metric developed using accelerometer data in the UK Biobank (N = 85,233; aged 43-79 years). USP captures five domains: sleep timing, efficiency, duration, rhythmicity, and regularity. Phenome-wide association study found that USP was significantly associated with 76 out of 526 incident health outcomes over 7.9 years of follow-up. We identified several upstream environmental risk factors associated with USP, including low socioeconomic status. Whole-genome sequence analyses identified common variants in MEIS1 and rare coding variants in TTC1 associated with USP. We validated the USP framework in an independent cohort, the Multi-Ethnic Study of Atherosclerosis. Our findings underscore the importance of multidimensional sleep health assessment in predicting and potentially mitigating a wide array of health disorders and advance genetic insights into sleep health.</p>
13 Keywords
- Adult
- Aged
- Female
- Genome-Wide Association Study
- Homeodomain Proteins
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Risk Factors
- Sleep
- Sleep Wake Disorders
- United Kingdom
6 Authors
- Shengkui Zhang
- Manrui Zhang
- Yuxin Yuan
- Zilin Li
- Xihao Li
- Xiaoyu Li
1 Application
| Application ID | Title |
|---|---|
| 91486 | Social, lifestyle, and biological risk factors of age-related diseases and mortality |
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