| Title: | Associations of accelerometer-measured weekend sleep catch-up and loss with risk of type 2 diabetes: a prospective cohort study |
| Journal: | Diabetes Research and Clinical Practice |
| Published: | 22 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40850509/ |
| DOI: | https://doi.org/10.1016/j.diabres.2025.112420 |
Publication 16067
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Abstract
AIMS: To investigate the relationship between weekend sleep catch-up and loss and risk of type 2 diabetes (T2D).</p>
METHODS: This study included 80,414 adults aged 43-79 years from the UK Biobank. Weekend sleep catch-up and loss were derived from wrist-worn accelerometer data. Cox hazard models were used to examine the associations of weekend sleep catch-up and loss with T2D risk (identified from linked medical records, death registers and self-reported diagnosis). Leveraging metabolic biomarker and metabolomics data, we further explored the underlying biological mechanisms.</p>
RESULTS: Over a median (IQR) follow-up of 7.3 years (6.8-7.8 years), 1,465 T2D cases occurred, with a cumulative incidence of 1.8 %. Among individuals with short weekday sleep duration, weekend sleep catch-up >1.5 h was associated with lower T2D risk (HR 0.64, 95 % CI 0.45-0.92). Conversely, among individuals with normal weekday sleep duration, weekend sleep loss was associated with higher T2D risk (HR 1.33, 95 % CI 1.01-1.76). Weekend sleep catch-up and loss showed distinct metabolic biomarker and metabolomic responses. Tyrosine, leucine, creatinine, and some lipid metabolites may link weekend sleep catch-up and loss to T2D.</p>
CONCLUSIONS: Weekend sleep catch-up could be a potential strategy against T2D among individuals with sleep deprivation during weekdays.</p>
14 Keywords
- Accelerometry
- Adult
- Aged
- Biomarkers
- Diabetes Mellitus, Type 2
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- Sleep
- Sleep Deprivation
- United Kingdom
15 Authors
- Yinan Jiang
- Zou Su
- Sibo Liu
- Hongkun Di
- Qi Wu
- Wen Hu
- Tianzhu Qin
- Shili Zhou
- Jiawei Yin
- Ying Chen
- Xiang Cheng
- Gang Liu
- Liegang Liu
- Yanjun Guo
- Zhilei Shan
1 Application
| Application ID | Title |
|---|---|
| 68307 | Environmental and genetic determinants of morbidity and mortality among adults with cardiometabolic disorders |
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