| Title: | Do Genetics Predict Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia? |
| Journal: | Urologic Clinics of North America |
| Published: | 12 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41106977/ |
| DOI: | https://doi.org/10.1016/j.ucl.2025.07.001 |
Publication 16052
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Abstract
Benign prostatic hyperplasia (BPH) is a prevalent condition in aging men with significant genetic underpinnings. Twin studies suggest a heritability estimate ranging from 40%-70%, and historic segregation analyses suggest possible autosomal dominant heritability pattern. However, no single gene mutation has been identified and validated as a common cause of lower urinary tract symptoms/BPH. Genome-wide association study approaches have identified numerous low-effect variants that contribute to polygenic risk of BPH. This article integrates recent advances in BPH genetics with clinical insights and outlines future research directions for personalized risk stratification.</p>
6 Keywords
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lower Urinary Tract Symptoms
- Male
- Prostatic Hyperplasia
3 Authors
- Alexander P Glaser
- Jianfeng Xu
- Brian T Helfand
1 Application
| Application ID | Title |
|---|---|
| 50295 | Validity and performance of inherited risk assessment for common diseases using polygenic risk score, family history, and high-penetrance genes |
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