| Title: | Association between alcoholic beverage consumption and cerebral small vessel disease burden |
| Journal: | The Journal of Prevention of Alzheimer's Disease |
| Published: | 2 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40754514/ |
| DOI: | https://doi.org/10.1016/j.tjpad.2025.100322 |
Publication 16039
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Abstract
BACKGROUND: The relationship between alcohol consumption and cerebral small vessel disease (CSVD) remains uncertain, particularly regarding drinking patterns and beverage types. We investigated how total alcohol intake, drinking frequency, and beverage-specific consumption are associated with CSVD burden using cross-sectional data.</p>
METHODS: We included 27,326 UK Biobank (UKB) participants with MRI data, among whom 21,130 were current drinkers with full alcohol intake data. Alcohol consumption (frequency and beverage type) was self-reported. CSVD burden was measured via normalized white matter hyperintensity volume (WMHV) on T2-FLAIR MRI. Multivariable linear regression models adjusted for demographics, lifestyle, and vascular risk factors were used to examine associations.</p>
RESULTS: Compared with non-drinkers, alcohol consumers had greater CSVD burden (Beta = 0.07; 95 % CI, 0.00-0.15). Among them, higher drinking frequency (≥5 times/week) was associated with increased CSVD burden (Beta = 0.10; 95 % CI, 0.07-0.13). High consumption of red wine, white wine/champagne, and spirits (≥7 servings/week) correlated positively with CSVD burden. In contrast, low-to-moderate beer/cider intake (≤3 servings/week) was inversely associated with burden. A dose-response relationship between total ethanol intake and CSVD burden was observed, with minimal intake (<1.97 g/day) showing a mild negative association, and higher levels increasing risk.</p>
CONCLUSION: Greater frequency and volume of alcohol intake, especially from wine and spirits, are linked with higher CSVD burden. Conversely, low beer/cider consumption may be inversely associated with CSVD burden. These findings underscore the importance of moderating alcohol consumption to maintain cerebrovascular health.</p>
7 Authors
- Ben-Bo Xiong
- Zi-Jie Wang
- Zhi-Ming Li
- Tian-Nan Yang
- Xiang-Yu Li
- Meng-Jie Lu
- Qi Li
1 Application
| Application ID | Title |
|---|---|
| 100889 | Role of vascular and behavioral risk factors, genes and imaging markers in cerebrovascular disease and cognitive impairment |
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