| Title: | Elucidating the Relationship Between Body Fat Index and Pulmonary Health: Insights from Cross-Sectional Analysis and Mendelian Randomization |
| Journal: | International Journal of Chronic Obstructive Pulmonary Disease |
| Published: | 1 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40191267/ |
| DOI: | https://doi.org/10.2147/copd.s488523 |
| URL: | https://www.dovepress.com/article/download/101631 |
Publication 15992
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Abstract
Objective: To evaluate the relationship between body fat index and pulmonary health.</p>
Methods: In the multiethnic population-based cross-sectional study, a multivariable linear regression model was adapted to assess the association of fat mass/percentage with forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC). The Mendelian Randomization (MR) method was used to assess the causal associations of fat mass/percentage in specific body parts with FEV1 and COPD risk. Sensitivity analysis of MR was performed to assess the robustness of estimates.</p>
Results: In the cross-sectional analysis, a non-linear relationship was observed between fat mass and FEV1 without adjustment. After multivariate adjustment, the negative associations of fat mass/percentage with FEV1/FVC were found. In the MR study, genetically determined fat presented a negative causal effect on FEV1 (e.g., estimate = -0.170, P < 0.001 for left leg fat mass). The causal associations of genetically determined body fat with clinical diagnosis COPD were also determined (e.g., OR = 1.936, P < 0.001 per 1.9 kilograms increase in left leg fat mass).</p>
Conclusion: We present strong evidence on the causal relationship between body fat mass/percentage and both the deterioration of lung function and the increased risk of COPD. Additional efforts are required to mitigate the negative effects of body fat.</p>
19 Keywords
- Adipose Tissue
- Adiposity
- Adult
- Aged
- Cross-Sectional Studies
- Female
- Forced Expiratory Volume
- Genetic Predisposition to Disease
- Humans
- Linear Models
- Lung
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Phenotype
- Pulmonary Disease, Chronic Obstructive
- Risk Assessment
- Risk Factors
- Vital Capacity
11 Authors
- Qing Zhang
- Zihui Wang
- Weijuan Liu
- Guannan Cai
- Yuan Gao
- Yilin Chen
- Yuan Han
- Anliu Nie
- Ruan Liang
- Fei Cui
- Ying Chen
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