| Title: | Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia |
| Journal: | Nephrology Dialysis Transplantation |
| Published: | 13 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40080089/ |
| DOI: | https://doi.org/10.1093/ndt/gfae255 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/11905747 |
Publication 15976
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Abstract
Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10-15% of the adult population, with higher prevalence in the elderly, who are already at increased risk for cognitive decline. Cognitive impairment is notably higher in CKD patients, particularly those with severe stages of the disease, and progresses more rapidly in those on dialysis. This review explores how data from large biobank studies such as the Alzheimer's Disease Neuroimaging Initiative, UK Biobank, and others could be used to enhance understanding the progression and interplay between CKD and cognitive decline. Each of these data sources has specific strengths and limitations. Strengths include large sample sizes and longitudinal data across different groups, and in different settings. Addressing limitations leads to challenges in dealing with heterogeneous data collection methods, and addressing missing data, which requires the use of sophisticated statistical techniques. Combining data from multiple databases can mitigate individual study limitations, particularly via the 'epidemiological triangulation' concept. Using such data appropriately holds immense potential to better understand the pathobiology underlying CKD and cognitive impairment. Addressing the inherent challenges with a clear strategy is crucial for advancing our understanding and improving the lives of those affected by both CKD and cognitive impairment.</p>
7 Keywords
- Big Data
- Biological Specimen Banks
- Cognitive Dysfunction
- Databases, Factual
- Dementia
- Humans
- Renal Insufficiency, Chronic
129 Authors
- Carmine Zoccali
- Francesca Mallamaci
- Kerry Rosenberg
- Robert Unwin
- Pedro Imenez Silva
- Maria Adelina Simeoni
- Gaye Hafez
- Giovambattista Capasso
- Dorothea Nitsch
- Giovambattista Capasso
- Alexandre Andrade
- Mustafa Arici
- Maie Bachmann
- Matthew Bailey
- Michelangela Barbieri
- Mickaël Bobot
- Annette Bruchfeld
- Inga Arune-Bumblyte
- Daiva Rastenytė
- Antonello Calcutta
- Giovanna Capolongo
- Sol Carriazo
- Michele Ceccarelli
- Adrian Constantin Covic
- Ananya De
- Pilar Delgado
- Nicole Endlich
- Matthias Endres
- Fabrizio Esposito
- Michele Farisco
- Quentin Faucher
- Ana Carina Ferreira
- Andreja Figurek
- Denis Fouque
- Casper Franssen
- Ivo Fridolin
- Sebastian Frische
- Liliana Garneata
- Loreto Gesualdo
- Konstantinos Giannakou
- Olivier Godefroy
- Aleksandra Golenia
- Dimitrios Goumenos
- Eugenio Gutiérrez Jiménez
- Gaye Hafez
- Ewout Hoorn
- Pedro Henrique Imenez Silva
- Raafiah Izhar
- Dearbhla Kelly
- Shelli Kesler
- Aleksandra Klimkowicz-Mrowiec
- Samuel Knauss
- Justina Kurganaite
- Hélène Levassort
- Sophie Liabeuf
- Jolanta Malyszko
- Laila-Yasmin Mani
- Gianvito Martino
- Ziad Massy
- Christopher Mayer
- Armida Mucci
- Alma Mutevelic-Turkovic
- Rikke Nielsen
- Dorothea Nitsch
- Alberto Ortiz
- Vasileios Panagiotopoulos
- Despoina Karasavvidou
- Giuseppe Paolisso
- Bojana Pejušković
- Marion Pepin
- Alessandra Perna
- Andrea Perrottelli
- Vesna Pešić
- Pasquale Pezzella
- Merita Rroji
- Ivan Rychlík
- Giorgos Sakkas
- Mariadelina Simeoni
- Maria José Soler Romeo
- Goce Spasovski
- Ana Starčević
- Gioacchino Tedeschi
- Francesco Trevisani
- Robert Unwin
- Evgueniy Vazelov
- Carsten Alexander Wagner
- Franca Wagner
- Christoph Wanner
- Andrzej Wiecek
- Hong Xu
- Miriam Zacchia
- Lefteris Zacharia
- Irene Zecchino
- Carmine Zoccali
- Francesco Mattace-Raso
- Karl-Hans Endlich
- Norberto Perico
- Giuseppe Remuzzi
- Francesco Trepiccione
- Mark Okusa
- Vincenzo Di Marzo
- Peter Blankestijn
- Kai-Uwe Eckardt
- Maximilian Konig
- Ron Gansevoort
- Hassan Askari
- Brian Hansen
- Sunna Snaedal
- Elena Cuiban
- Edoardo Caporusso
- Vincenzina Lo Re
- Jonathan Roiser
- Kerry Rosenberg
- Alvino Bisecco
- Laura Denby
- Onkar Prakash Kulkarni
- Kumar Sharma
- Subrata Debnath
- Afaf Jaafar
- Anna Capasso
- Michele Mulholland
- Biruh Workeneh
- Anna Iervolino
- Simon Fraser
- Isabelle Frey-Wagner
- Annachiara Pastore
- Antonio De Donato
- Romaldas Mačiulaitis
- Ana Farinha
Enabling scientific discoveries that improve human health