| Title: | Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk |
| Journal: | BMC Medicine |
| Published: | 26 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40001093/ |
| DOI: | https://doi.org/10.1186/s12916-024-03833-x |
Publication 15924
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BackgroundSleep, physical activity, and nutrition (SPAN) are critical behaviours for health, although they have traditionally been studied separately. We examined the combined associations of SPAN and the minimum between-individual variations associated with meaningfully lower all-cause mortality risk.MethodsThis prospective cohort analysis included 59,078 participants from the UK Biobank (median age: 64.0 years; 45.4% male) who wore trackers for 7 days and self-reported dietary data. Wearable-measured sleep (hours/day) and moderate to vigorous physical activity (MVPA; mins/day) were calculated using a machine learning based schema. A 10-item diet quality score (DQS) assessed the intake of vegetables, fruits, fish, dairy, whole grains, vegetable oils, refined grains, processed and unprocessed meats, and sugary beverages (0-100 for all components with higher values indicating higher quality). Cox proportional hazards models were used to estimate hazard ratios (HR) for all-cause mortality risk across 27 separate joint tertile combinations of SPAN behaviours with the lowest tertile for all three as the referent group. For more granular clinical interpretations, we examined combined incremental dose-response changes of the SPAN behaviours using the 5th percentile of each behaviour as the referent point.ResultsOver the 8.1-year median follow-up time, 2,458 mortality events occurred. Compared to the referent group of combined SPAN exposure (lowest tertiles for all three), the optimal SPAN combination involving moderate sleep duration (7.2-8.0 h/day), high MVPA (42-103 min/day), and a DQS between 57.5 and 72.5 was associated with an HR of 0.36 (95% CI: 0.26-0.50). Relative to the 5th percentile of sleep (5.5 h/day), physical activity (7.3 min/day), and nutrition (36.9 DQS), a theoretical minimum combined increase of 15 min/day of sleep, 1.6 min/day MVPA, and 5 DQS points (corresponding to e.g., extra 1/2 serving of vegetables per day or 1 less serving of processed meat per week) was associated with 10% lower all-cause mortality risk (0.90; 0.88-0.93). Combined increases of 75 min/day of sleep, 12.5 min/day MVPA, and 25 DQS points were associated with 50% lower all-cause mortality risk (0.50; 0.44-0.58).ConclusionsThis study highlights the potential health value of subtle combined SPAN modification in relation to mortality risk and expands opportunities for more holistic recommendations.</p>
13 Keywords
- Aged
- Diet
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Mortality
- Nutritional Status
- Prospective Studies
- Risk Factors
- Sleep
- United Kingdom
17 Authors
- Emmanuel Stamatakis
- Nicholas A. Koemel
- Raaj K. Biswas
- Matthew N. Ahmadi
- Margaret Allman-Farinelli
- Stewart G. Trost
- Elif Inan-Eroglu
- Borja del Pozo Cruz
- Yu Sun Bin
- Svetlana Postnova
- Mitch J. Duncan
- Dorothea Dumuid
- Helen Brown
- Carol Maher
- Luigi Fontana
- Stephen Simpson
- Peter A. Cistulli
1 Application
| Application ID | Title |
|---|---|
| 25813 | Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health. |
Enabling scientific discoveries that improve human health