| Title: | Early detection of Parkinson's disease through multiplex blood and urine biomarkers prior to clinical diagnosis |
| Journal: | npj Parkinson's Disease |
| Published: | 25 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39994191/ |
| DOI: | https://doi.org/10.1038/s41531-025-00888-2 |
| URL: | https://www.nature.com/articles/s41531-025-00888-2.pdf |
Publication 15906
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Abstract
Blood and urine biomarkers are commonly used to diagnose and monitor chronic diseases. We initially screened 67 biomarkers, including 4 urine biomarkers and 63 blood biomarkers, and identified 13 blood biomarkers significantly associated with Parkinson's disease (PD). Among these, we discovered three novel markers demonstrating strong associations: phosphate (P = 1.81 × 10−3), AST/ALT ratio (P = 8.53 × 10−6), and immature reticulocyte fraction (IRF) (P = 3.49 × 10−20). We also substantiated eight well-studied biomarkers and elucidated the roles of two previously ambiguous biomarkers. Our analyses confirmed IGF-1 (P = 7.46 × 10−29) as a risk factor, and C-reactive protein (CRP) (P = 1.43 × 10−3) as protective against PD. Genetic analysis highlighted that IRF, CRP, and IGF-1 share significant genetic loci with PD, notably at MAPT, SETD1A, HLA-DRB1, and HLA-DQA1. Furthermore, Mendelian randomization (MR) analysis suggested potential causal associations between IGF-1, CRP, and PD. We identified several blood biomarkers that may be associated with the risk of developing PD, providing valuable insights for further exploration of PD-related biomarkers.</p>
14 Authors
- Shuo Gao
- Zheng Wang
- Yuanfeng Huang
- Guang yang
- Yijing Wang
- Yan Yi
- Qiao Zhou
- Xingxing Jian
- Guihu Zhao
- Bin Li
- Linyong Xu
- Kun Xia
- Beisha Tang
- Jinchen Li
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