| Title: | Association between a healthy lifestyle and dementia in older adults with obesity: A prospective study in the UK biobank |
| Journal: | Journal of Affective Disorders |
| Published: | 25 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40147612/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.03.115 |
Publication 15859
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Abstract
BACKGROUND: The impact of adherence to low-risk lifestyle factors on dementia risk in individuals with obesity remains unclear. We aimed to explore the association between healthy lifestyles with dementia in obese participants.</p>
METHODS: Dementia-free participants from the UK Biobank, aged 50 years or older with obesity (BMI ≥30 kg/m2) at baseline were included. A weighted healthy lifestyle score was calculated incorporating both traditional and emerging lifestyle factors. The primary outcome was all-cause dementia and its subtypes (Alzheimer's disease and Vascular dementia). Cox regression models analyzed the association between healthy lifestyle scores and dementia risk. Restricted cubic splines tested the dose-response. We also examined the effect of lifestyle scores on dementia risk in individuals with normal weight and overweight.</p>
RESULTS: A total of 54,365 participants were included at baseline. During a median follow-up of 14.4 years, 1271 participants developed all-cause dementia, including 537 cases of Alzheimer's disease and 343 cases of vascular dementia. A 20 % increase in the lifestyle score was associated with a 7 % reduction in dementia risk (HR: 0.93; 95 % CI: 0.91,0.96) and a 4 % reduction in Alzheimer's disease risk (HR: 0.96; 95 % CI: 0.92,1.00). The association was stronger in overweight and obese participants. No significant link was found for vascular dementia.</p>
LIMITATIONS: Information on lifestyle behaviors was self-reported and might be prone to measurement error.</p>
CONCLUSIONS: Adherence to a healthy lifestyle may reduce the risk of dementia and Alzheimer's disease in older obese individuals, with a stronger effect observed in those with higher lifestyle scores.</p>
11 Authors
- Junru Wang
- Jiahui Zhang
- Yongbin Zhu
- Xiaojun Ma
- Yali Wang
- Kai Liu
- Zhuoyuan Li
- Jing Wang
- Renzhang Liang
- Shulan He
- Jiangping Li
1 Application
| Application ID | Title |
|---|---|
| 98124 | Understanding the patterns of multimorbidity, and the role of environmental, lifestyle-related, psychological and genetic factors |
Enabling scientific discoveries that improve human health