| Title: | Amount and intensity of daily total physical activity, step count and risk of incident cancer in the UK Biobank |
| Journal: | British Journal of Sports Medicine |
| Published: | 26 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40139674/ |
| DOI: | https://doi.org/10.1136/bjsports-2024-109360 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/12242917 |
Publication 15841
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Abstract
OBJECTIVES: To investigate associations between daily physical activity, activity intensity and step counts with incident cancer risk.</p>
METHODS: Prospective analysis of UK Biobank participants who wore wrist-based accelerometers for 7 days, followed for cancer incidence (mean follow-up 5.8 years, SD 1.3). Time-series machine-learning models derived total physical activity, sedentary behaviour (SB), light-intensity physical activity (LIPA), moderate-vigorous-intensity physical activity (MVPA) and step counts. The outcome was a composite of 13 cancers previously associated with low physical activity in questionnaire-based studies. Cox proportional hazard models estimated HRs and 95% CIs, adjusted for demographic, health and lifestyle factors. We also explored associations of LIPA, MVPA and SB with cancer risk.</p>
RESULTS: Among 85 394 participants (median age 63 (IQR 56-68)), 2633 were diagnosed with cancer during follow-up. Compared with individuals in the lowest quintile of total physical activity (<21.6 milligravity units), those in the highest (34.3+) had a 26% lower cancer risk (HR=0.74 (95% CI 0.65 to 0.84)). After mutual adjustment, LIPA (HR=0.94 (95% CI 0.90 to 0.98)) and MVPA (HR=0.87 (95% CI 0.79 to 0.94)) were associated with lower risk, but SB was not. Similar associations were observed for substituting 1 hour/day of SB with LIPA or MVPA. Daily step counts were inversely associated with cancer, with the dose-response beginning to plateau at around 9 000 steps/day (HR=0.89 (95% CI 0.83 to 0.96) 7000 vs 5000 steps; HR=0.84 (95% CI 0.76 to 0.93) 9000 vs 5000 steps). There was no significant association between stepping intensity (peak 30-minute cadence) and cancer after adjusting for step count.</p>
CONCLUSION: Total physical activity, LIPA, MVPA and step counts were inversely associated with incident cancer.</p>
16 Keywords
- Accelerometry
- Aged
- Biological Specimen Banks
- Exercise
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasms
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sedentary Behavior
- UK Biobank
- United Kingdom
11 Authors
- Alaina H Shreves
- Scott R Small
- Rosemary Walmsley
- Shing Chan
- Pedro F Saint-Maurice
- Steven C Moore
- Keren Papier
- Kezia Gaitskell
- Ruth C Travis
- Charles E Matthews
- Aiden Doherty
1 Application
| Application ID | Title |
|---|---|
| 59070 | Statistical machine learning of wearable sensor data to predict disease outcomes |
Enabling scientific discoveries that improve human health