| Title: | Relation of high-density lipoprotein cholesterol, size and particle subclasses, genetic susceptibility with new-onset idiopathic pulmonary fibrosis |
| Journal: | Precision Nutrition |
| Published: | 27 Mar 2025 |
| DOI: | https://doi.org/10.1097/pn9.0000000000000102 |
| URL: | http://dx.doi.org/10.1097/pn9.0000000000000102 |
Publication 15830
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The objective of this study is to assess the relationship between high-density lipoprotein cholesterol (HDL-C) concentrations, high-density lipoprotein particle (HDL-P) size, and concentrations of HDL-P subclasses with different sizes with new-onset idiopathic pulmonary fibrosis (IPF). The longitudinal study included 404,023 participants without prior IPF from UK Biobank. The study outcome was new-onset IPF. Participants were divided into low, moderate, and high IPF genetic risks according to the tertiles of IPF genetic risk scores, calculated using a weighted method by 13 single nucleotide polymorphisms. During a median follow-up of 12.4 years, 1850 (4.6‰) participants developed IPF. There was a non-significant inverse association between HDL-C concentrations and the risk of new-onset IPF (per standard deviation [SD] increment, adjusted hazard ratio [HR], 0.95; 95% confidence interval [CI]: 0.89-1.02). HDL-P average size (per SD increment, adjusted HR, 1.37; 95% CI: 1.16-1.63), very large-sized (per SD increment, adjusted HR, 1.22; 95% CI: 1.04-1.43), and large-sized HDL-P concentrations (per SD increment, adjusted HR, 1.30; 95% CI: 1.04-1.63) were significantly positively associated with the risk of new-onset IPF. Medium-sized HDL-P concentrations were not significantly associated with the risk of new-onset IPF (per SD increment, adjusted HR, 0.99; 95% CI: 0.83-1.20). Small-sized HDL-P concentrations were significantly inversely associated with the risk of new-onset IPF (per SD increment, adjusted HR, 0.86; 95% CI: 0.77-0.96), especially in participants with low or moderate genetic risks of IPF and without diabetes (all P interactions <0.05). Small-sized HDL-P concentrations were inversely associated with the risk of new-onset IPF, while HDL-P sizes and larger-sized HDL-P concentrations were positively associated with the risk of new-onset IPF.</p>
8 Authors
- Yuanyuan Zhang
- Ziliang Ye
- Yu Huang
- Hao Xiang
- Yanjun Zhang
- Sisi Yang
- Xiaoqin Gan
- Xianhui Qin
1 Application
| Application ID | Title |
|---|---|
| 73201 | Identification of residual risks of non-infectious chronic diseases |
Enabling scientific discoveries that improve human health