| Title: | A genome-wide association study of imaging-defined atherosclerosis |
| Journal: | Nature Communications |
| Published: | 31 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40164586/ |
| DOI: | https://doi.org/10.1038/s41467-025-57457-7 |
Publication 15814
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Abstract
Imaging-defined atherosclerosis represents an intermediate phenotype of atherosclerotic cardiovascular disease (ASCVD). Genome-wide association studies (GWAS) on directly measured coronary plaques using coronary computed tomography angiography (CCTA) are scarce. In the so far largest population-based cohort with CCTA data, we performed a GWAS on coronary plaque burden as determined by the segment involvement score (SIS) in 24,811 European individuals. We identified 20 significant independent genetic markers for SIS, three of which were found in loci not implicated in ASCVD before. Further GWAS on coronary artery calcification showed similar results to that of SIS, whereas a GWAS on ultrasound-assessed carotid plaques identified both shared and non-shared loci with SIS. In two-sample Mendelian randomization studies using SIS-associated markers in UK Biobank and CARDIoGRAMplusC4D, one extra coronary segment with atherosclerosis corresponded to 1.8-fold increased odds of myocardial infarction. This GWAS data can aid future studies of causal pathways in ASCVD.</p>
17 Keywords
- Aged
- Atherosclerosis
- Cohort Studies
- Computed Tomography Angiography
- Coronary Angiography
- Coronary Artery Disease
- Female
- Genetic Markers
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Myocardial Infarction
- Plaque, Atherosclerotic
- Polymorphism, Single Nucleotide
25 Authors
- Anders Gummesson
- Per Lundmark
- Qiao Sen Chen
- Elias Björnson
- Koen F. Dekkers
- Ulf Hammar
- Martin Adiels
- Yunzhang Wang
- Therese Andersson
- Göran Bergström
- Carl-Johan Carlhäll
- David Erlinge
- Tomas Jernberg
- Fredrik Landfors
- Lars Lind
- Maria Mannila
- Olle Melander
- Carlo Pirazzi
- Johan Sundström
- Carl Johan Östgren
- Cecilia Gunnarsson
- Marju Orho-Melander
- Stefan Söderberg
- Tove Fall
- Bruna Gigante
1 Application
| Application ID | Title |
|---|---|
| 82018 | Improved biomarkers of cardiovascular disease |
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