| Title: | Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank |
| Journal: | Investigative Ophthalmology & Visual Science |
| Published: | 22 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40261662/ |
| DOI: | https://doi.org/10.1167/iovs.66.4.63 |
| URL: | https://iovs.arvojournals.org/arvo/content_public/journal/iovs/938709/i1552-5783-66-4-63_1745313833.67085.pdf |
Publication 15793
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Abstract
Purpose: This study aimed to investigate the correlation between cardiovascular health (CVH), evaluated through the Life's Essential 8 (LE8) score, and the risk of new-onset age-related macular degeneration (AMD).</p>
Methods: This longitudinal analysis included 271,274 participants who were free of both cardiovascular diseases and AMD at baseline. The LE8 score was classified into three categories: low (<50 points), moderate (50 to <80 points), and high (≥80 points), with higher scores indicating better CVH. Cox proportional hazards models were used to explore the relationships between the CVH and AMD incidence. Furthermore, the population attributable risk (PAR%) was calculated for CVH and each individual metric.</p>
Results: During an average follow-up duration of 10.9 years, a total of 7468 (2.8%) cases of AMD were documented. Individuals with moderate and high CVH levels had a 14% (hazard ratio [HR] = 0.86; 95% confidence interval [CI], 0.78-0.94) and 23% (HR = 0.77; 95% CI, 0.69-0.86) reduced risk of developing AMD, respectively. A linear dose-response relationship was identified between the cumulative LE8 score and the incidence of AMD. Attaining optimal CVH in all individuals could potentially avert 9.4% (95% CI, 3.7%-15.1%) of AMD cases. Among the CVH metrics, ideal blood glucose and blood pressure levels were related to a reduction of 3.3% and 8.7% in AMD cases, respectively.</p>
Conclusions: Enhanced CVH is significantly associated with a reduced risk of developing AMD. Promoting CVH through the LE8 guideline might potentially contribute to the prevention of AMD.</p>
16 Keywords
- Aged
- Aged, 80 and over
- Biological Specimen Banks
- Cardiovascular Diseases
- Female
- Follow-Up Studies
- Humans
- Incidence
- Longitudinal Studies
- Macular Degeneration
- Male
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- UK Biobank
- United Kingdom
15 Authors
- Yu Peng
- Yuzhou Zhang
- Ka Wai Kam
- Gavin Wong
- Mary Ho
- Simon Sezto
- Sunny Au
- Xiujuan Zhang
- Mandy P. H. Ng
- Patrick Ip
- Alvin Young
- Chi Pui Pang
- Clement C. Tham
- Li Jia Chen
- Jason C. Yam
Enabling scientific discoveries that improve human health