| Title: | Associations of healthy lifestyle and accelerated aging with incident breast cancer in pre- and postmenopausal women: a population-based cohort study |
| Journal: | Scientific Reports |
| Published: | 25 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40281065/ |
| DOI: | https://doi.org/10.1038/s41598-025-98625-5 |
Publication 15757
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Abstract
Breast cancer is one of the most common malignancies in women. This study aimed to explore the association between healthy lifestyle, biological aging and breast cancer risk in pre- and postmenopausal women. This study included 125,579 participants. Biological aging was calculated using the PhenoAge algorithm. Cox regression models and counterfactual mediation analysis was utilized. During an average follow-up of 13.65 years, 5418 breast cancers occurred. In the overall women participants, compared to the healthy lifestyle group, the HR (95% CI) for unhealthy lifestyle regarding incident breast cancer was 1.28 (1.13, 1.33). Compared to the lowest tertile of accelerated aging (AA), the HR (95% CI) for the highest tertile regarding breast cancer risk was 1.22 (1.14, 1.30). Consistent results observed only in postmenopausal participants. The joint effect of a healthy lifestyle and AA on breast cancer risk was statistically significant (P < 0.001). The AA-mediated breast cancer risk ratio was 17.69 (95% CI 8.19, 27.19) when comparing healthy to unhealthy lifestyles. In the study, healthy lifestyle and lower levels of AA were significantly associated with a reduced risk of breast cancer, particularly among postmenopausal women. In addition, AA mediated 17.02-17.69% of the link between lifestyle and breast cancer risk.</p>
14 Keywords
- Adult
- Aged
- Aging
- Breast Neoplasms
- Cohort Studies
- Female
- Healthy Lifestyle
- Humans
- Incidence
- Life Style
- Middle Aged
- Postmenopause
- Premenopause
- Risk Factors
8 Authors
- Wenyi Liu
- Mengqing Yan
- Zhixing Fan
- Zhongli Ma
- Yuanhang Zhu
- Hui Chang
- Ruoxin Jiang
- Chenchen Ren
1 Application
| Application ID | Title |
|---|---|
| 170605 | Association analysis, causal inference, and modeling of genetic, environmental, lifestyle, and clinical determinants in the occurrence, progression, and prognosis of age-related diseases |
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