| Title: | Association of Social Disconnection With the Incidence and Prognosis of Atrial Fibrillation: A Multistate Analysis |
| Journal: | Journal of the American Heart Association |
| Published: | 25 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40281650/ |
| DOI: | https://doi.org/10.1161/jaha.124.039885 |
Publication 15746
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Abstract
BACKGROUND: Social disconnection, including loneliness and social isolation, is associated with increased morbidity and death. However, its impact on the incidence and prognosis of atrial fibrillation (AF) remains inconclusive.</p>
METHODS AND RESULTS: The present prospective cohort study enrolled 418 656 participants without AF and cardiovascular disease from the UK Biobank. A loneliness scale was constructed with 2 domains (loneliness feeling, inability to confide) and social isolation scale was constructed with 3 domains (living alone, lack of social support, and lack of social activity). We used a multistate model to analyze the impacts of the 2 scales on the progression from baseline to incident AF and subsequent major adverse cardiovascular events and further to death. Over a median follow-up of 14.7 years, 25 539 participants developed incident AF, among whom 7283 developed incident major adverse cardiovascular events, and 5165 died. Social isolation and loneliness scales were associated with both a higher incidence and worse prognosis of AF, with hazard ratios per 1-point increase of 1.06 (95% CI, 1.04-1.09) for the loneliness scale and 1.03 (95% CI, 1.02-1.05) for the social isolation scale for incident AF, and 1.12 to 1.14 for the loneliness scale (all P<0.001) and 1.12 to 1.27 for the social isolation scale (all P<0.001) after AF development. Loneliness feeling and living alone may be important contributors.</p>
CONCLUSIONS: Loneliness and social isolation were both associated with a higher incidence and a worse prognosis of AF but to different extents. These observations highlight the importance of integrating social connection into the prevention and management of AF.</p>
15 Keywords
- Aged
- Atrial Fibrillation
- Female
- Humans
- Incidence
- Loneliness
- Male
- Middle Aged
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Social Isolation
- Social Support
- United Kingdom
7 Authors
- Yu Qiao
- Yuyang Wang
- Tingting Ge
- Yahong Liu
- Yuzhu Chen
- Guodong Niu
- Yifang Yuan
1 Application
| Application ID | Title |
|---|---|
| 179610 | The Risk Factors and Prognosis of Cardiovascular-Kidney-Metabolic (CKM) Conditions |
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