| Title: | Grip Strength and Age-Related Ocular Diseases: Insights from Observational, Mendelian Randomization, and Mediation Analyses |
| Journal: | Ophthalmology Science |
| Published: | 21 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40636510/ |
| DOI: | https://doi.org/10.1016/j.xops.2025.100831 |
Publication 15697
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Abstract
Objective: We aimed to examine the cross sectional and causal associations of grip strength with cataract, glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD) and probe the underlying mechanisms by evaluating the mediating role of metabolomic alterations.</p>
Design: Cross sectional study.</p>
Subjects: A total of 307 796 UK Biobank participants with grip strength and covariates data available.</p>
Methods: Logistic regression models were used to evaluate the associations between grip strength and age-related ocular diseases. Two-sample Mendelian randomization analyses were conducted to assess the causality. Metabolic biomarkers from plasma samples were measured through nuclear magnetic resonance (n = 152 376), and principal component (PC) analysis was implemented to identify metabolic patterns (PC1-PC8). The mediation effects of both metabolic biomarkers and metabolic patterns were examined.</p>
Main Outcome Measures: The prevalence of age-related ocular diseases.</p>
Results: Compared with the highest tertile of grip strength, the lowest tertile had a higher prevalence of cataract (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.24-1.39), glaucoma (OR, 1.23; 95% CI, 1.13-1.33), and DR (OR, 2.80; 95% CI, 2.32-3.38). Genetic-associated elevated grip strength of at least 1 hand was associated with a lower risk of developing cataracts, DR, and AMD. Mediation analyses showed metabolic patterns, characterized by altered lipids and omega-3 polyunsaturated fatty acids (PUFAs) decrement (i.e., PC2 and PC8), significantly mediated the association of grip strength with cataract and DR.</p>
Conclusions: Weaker grip strength is associated with cataracts, glaucoma, and DR. Metabolomic alterations, especially disrupted lipid metabolism and omega-3 PUFA decrement, serve to be the critical mediators.</p>
Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</p>
8 Authors
- Chao Chen
- Dongling Guo
- Jiaqi Meng
- Jiao Qi
- Keke Zhang
- Wenwen He
- Yih Chung Tham
- Xiangjia Zhu
1 Application
| Application ID | Title |
|---|---|
| 93118 | Associations of lifestyle risk factors, ocular diseases, and mental disorders. |
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