| Title: | Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases |
| Journal: | Renal Failure |
| Published: | 29 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40301327/ |
| DOI: | https://doi.org/10.1080/0886022x.2025.2482127 |
Publication 15683
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Abstract
BACKGROUND: The difference in estimated glomerular filtration rate (eGFR) derived from creatinine and cystatin C (eGFRdiff) has been noticed recently and the relationship with poor cardiovascular prognosis has been proven. However, primary prevention of the risk of coronary artery disease (CAD) is equally important but there is a lack of studies specifically investigating this implication.</p>
METHODS: This prospective cohort study utilized data from the UK Biobank, including 437,536 participants without CAD at baseline. The primary outcome was defined as CAD. The eGFRdiff was calculated by subtracting creatinine-based eGFR from cystatin C-based eGFR. Participants were then categorized into a negative, intermediate range, and positive group based on thresholds of -15 mL/min/1.73 m2 and 15 mL/min/1.73 m2. Cox proportional risk models were used to evaluate the associations of eGFRdiff with CAD and the relationship among different genetic risks of CAD.</p>
RESULTS: During a median follow-up of 13.8 years, CAD occurred in 36,797 participants. In the fully adjusted model, compared to midrange eGFRdiff, participants with a positive eGFRdiff had a lower risk of CAD (HR 0.717, 95%CI 0.675-0.762), while with a negative eGFRdiff had a higher risk (HR 1.433, 95%CI 1.399-1.468). When eGFRdiff was treated as a continuous variable, a statistically significant trend toward a lower risk of CAD as eGFRdiff increased (HR 0.982, 95% CI 0.981-0.982). Moreover, this relationship is independent of genetic susceptibility.</p>
CONCLUSIONS: eGFRdiff was associated with CAD risk, where a high eGFRdiff corresponded to a decreased likelihood of CAD onset no matter genetic susceptibility.</p>
15 Keywords
- Aged
- Biomarkers
- Coronary Artery Disease
- Creatinine
- Cystatin C
- Female
- Glomerular Filtration Rate
- Humans
- Male
- Middle Aged
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- United Kingdom
5 Authors
- Zechen Liu
- Wangying Jiang
- Yanjun Song
- Kefei Dou
- Weihua Song
1 Application
| Application ID | Title |
|---|---|
| 97155 | Association of the life pattern with the risk of myocardial infarction (MI) in people without standard modifiable cardiovascular risk factors (SMuRFs) |
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