| Title: | Independent and combined effects of long-term air pollution exposure and genetic predisposition on COVID-19 severity: A population-based cohort study |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 3 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40030018/ |
| DOI: | https://doi.org/10.1073/pnas.2421513122 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/11912415 |
Publication 15658
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Abstract
The relationships between air pollution, genetic susceptibility, and COVID-19-related outcomes, as well as the potential interplays between air pollution and genetic susceptibility, remain largely unexplored. The Cox proportional hazards model was used to assess associations between long-term exposure to air pollutants and the risk of COVID-19 outcomes (infection, hospitalization, and death) in a COVID-19-naive cohort (n = 458,396). Additionally, associations between air pollutants and the risk of COVID-19 severity (hospitalization and death) were evaluated in a COVID-19 infection cohort (n = 110,216). Furthermore, this study investigated the role of host genetic susceptibility in the relationships between exposure to air pollutants and the development of COVID-19-related outcomes. Long-term exposure to air pollutants was significantly associated with an increased risk of COVID-19-related outcomes in the COVID-19 naive cohort. Similarly, in COVID-19 infection cohort, hazard ratios (HRs) for COVID-19 hospital admission were 1.23 (1.19, 1.27) for PM2.5 and 1.22 (1.17, 1.26) for PM10, whereas HRs for COVID-19 death were 1.28 (1.18, 1.39) for PM2.5 and 1.25 (1.16, 1.36) for PM10. Notably, significant interactions were found between PM2.5/PM10 and genetic susceptibility in COVID-19 death. In COVID-19 infection cohort, participants with both high genetic risk and high air pollutants exposure had 1.86- to 1.97-fold and 1.91- to 2.14-fold higher risk of COVID-19 hospitalization and death compared to those with both low genetic risk and low air pollutants exposure. Exposure to air pollution is significantly associated with an increased burden of severe COVID-19, and air pollution-gene interactions may play a crucial role in the development of COVID-19-related outcomes.</p>
17 Keywords
- Adult
- Aged
- Air Pollutants
- Air Pollution
- COVID-19
- Cohort Studies
- Environmental Exposure
- Female
- Genetic Predisposition to Disease
- Hospitalization
- Humans
- Male
- Middle Aged
- Particulate Matter
- Proportional Hazards Models
- SARS-CoV-2
- Severity of Illness Index
7 Authors
- Yudiyang Ma
- Jianing Wang
- Feipeng Cui
- Linxi Tang
- Sara Khalid
- Yaohua Tian
- Junqin Xie
1 Application
| Application ID | Title |
|---|---|
| 69741 | Environmental exposures, medicine use, genetic susceptibility, and the risk of cardiovascular diseases and psychiatric disorders |
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