| Title: | Both general and central obesity are associated with increased risk of irritable bowel syndrome: a large-scale prospective cohort study |
| Journal: | American Journal of Clinical Nutrition |
| Published: | 5 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40054622/ |
| DOI: | https://doi.org/10.1016/j.ajcnut.2025.03.001 |
Publication 15651
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Abstract
BACKGROUND: Obesity has emerged as a major public health concern worldwide. However, the relationship between obesity and irritable bowel syndrome (IBS) remains unclear.</p>
OBJECTIVES: We aimed to systematically examine the association of both general and central obesity measures with risk of incident IBS in a large population-based cohort.</p>
METHODS: Participants free of IBS, celiac disease, inflammatory bowel disease, and any cancer at baseline were included. Obesity was assessed using various measures of general and central obesity [i.e., Body mass index (BMI in kg/m2), waist circumference, etc.]. The primary outcome was incident IBS. The Cox proportional hazard model was conducted to estimate the association.</p>
RESULTS: Among 416,124 participants (mean age 56.2 y), 133,775 (32.1%), 178,283 (42.8%) and 102,139 (24.5%) were BMI-defined normal, overweight and obesity at baseline. During a median of 14.6-y follow-up, 8744 (2.1%) incident IBS were identified. After multiple adjustments, individuals with obesity had a 7% higher risk of developing IBS than those with normal BMI [hazard ratio (HR): 1.07; 95% confidence interval (CI): 1.01, 1.13]. As for central obesity, individuals with the highest quartiles of waist circumference (HR: 1.14; 95% CI: 1.06, 1.27) and visceral adipose tissue volume (HR: 1.35; 95% CI: 1.04, 1.75) had a 14% and 35% greater risk of IBS compared with the lowest quartiles. A similar positive association was observed in other general and central obesity measures, with an 8-35% higher risk of IBS occurrence in the highest quartile compared with the reference group. Further sensitivity analyses and subgroup analyses demonstrated similar results.</p>
CONCLUSIONS: Both general and central obesity are associated with an increased risk of developing IBS, suggesting the importance of obesity management.</p>
7 Authors
- Shuang Yu
- Yesheng Zhou
- Si Liu
- Qian Zhang
- Shutian Zhang
- Shengtao Zhu
- Shanshan Wu
1 Application
| Application ID | Title |
|---|---|
| 74444 | Common risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome |
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