| Title: | Accelerometer-Derived "Weekend Warrior" Physical Activity and All-Cause and Cause-Specific Mortality |
| Journal: | Mayo Clinic Proceedings |
| Published: | 7 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40057865/ |
| DOI: | https://doi.org/10.1016/j.mayocp.2024.10.022 |
Publication 15640
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Abstract
OBJECTIVE: To examine the association of "weekend warrior" (WW) pattern and physical activity distributed throughout the week with mortality risk.</p>
PARTICIPANTS AND METHODS: In this cohort study of 95,468 participants in the UK Biobank from 2013 through 2015, participants were grouped by accelerometer-derived physical activity levels: inactive (moderate to vigorous physical activity [MVPA] <150 min/wk using World Health Organization guidelines), active WW (≥150 minutes of MVPA per week and ≥50% of total MVPA over 1 to 2 days), and active regular (≥150 minutes of MVPA but not active WW). Cox regression analyzed associations of activity patterns with all-cause mortality and 10 categories of cause-specific mortality and whether the association differed by sedentary time (≤6, 7 to 12, or ≥13 hours) and light physical activity (≤60, 61 to 150, or ≥151 min/d).</p>
RESULTS: During the median 7.92 years of follow-up, 3539 deaths occurred. Compared with the inactive participants, the hazard ratio for all-cause mortality was 0.74 (95% CI, 0.68 to 0.82) in active regular participants and 0.72 (95% CI, 0.67 to 0.78) in active WW participants. Similar risk reductions were noted in most cause-specific deaths, especially for those from cancer, cardiovascular disease, and respiratory diseases. These benefits were more profound among participants with 13 or more hours of sedentary time (active regular: 0.58 [0.41 to 0.83]; active WW: 0.70 [0.55 to 0.88]) or 60 min/d or less of light physical activity (active regular: 0.59 [0.42 to 0.83]; active WW: 0.47 [0.35 to 0.63]). A similar reduction in all-cause mortality risk was observed across different age groups regardless of activity frequency and timing.</p>
CONCLUSION: Physical activity evenly distributed throughout the week and concentrated within 1 to 2 days are both associated with similar lower risks of all-cause mortality and most categories of cause-specific mortality.</p>
15 Keywords
- Accelerometry
- Adult
- Aged
- Cause of Death
- Cohort Studies
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Mortality
- Proportional Hazards Models
- Sedentary Behavior
- Time Factors
- United Kingdom
8 Authors
- Chen Huang
- Yahang Liu
- Ruilang Lin
- Ce Wang
- Ye Yao
- Guoyou Qin
- Yiliang Zhang
- Yongfu Yu
1 Application
| Application ID | Title |
|---|---|
| 96511 | Investigating the genome-wide association and risk factors for multi-organ ageing |
Enabling scientific discoveries that improve human health