| Title: | Genetic Susceptibility to Type 2 Diabetes, Television Viewing, and Atherosclerotic Cardiovascular Disease Risk |
| Journal: | Journal of the American Heart Association |
| Published: | 12 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40071666/ |
| DOI: | https://doi.org/10.1161/jaha.124.036811 |
Publication 15614
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Abstract
BACKGROUND: Type 2 diabetes (T2D) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). This study examined the interplay between watching television and T2D genetic risk for risk of ASCVD.</p>
METHODS: We included 346 916 White British individuals from UK Biobank. A weighted polygenic risk score for T2D was calculated on the basis of 138 genetic variants associated with T2D. Time spent watching television was self-reported and categorized into 2 groups: ≤1 h/d and ≥2 h/d. Over a median 13.8-year follow-up, 21 265 incident ASCVD events were identified. Models using Cox regression with age as the underlying time scale adjusted for potential confounders (demographic, anthropometric, lifestyle factors, and medication use) were fit.</p>
RESULTS: Compared with watching television for ≤1 h/d, watching ≥2 h/d was associated with 12% (95% CI, 1.07-1.16) higher hazards of ASCVD, independently of T2D genetic risk. Joint analyses (with low T2D genetic risk and ≤1 h/d of television viewing as reference) indicated that medium and high T2D genetic risk was not associated with higher hazards of ASCVD as long as television viewing was ≤1 h/d. The P values for multiplicative and additive interactions between T2D genetic risk and television viewing were 0.050 and 0.038, respectively. The 10-year absolute risk of ASCVD was lower for high T2D genetic risk combined with ≤1 h/d of television viewing (2.13%) than for low T2D genetic risk combined with ≥2 h/d of television viewing (2.46%).</p>
CONCLUSIONS: Future clinical trials of lifestyle-modification interventions targeting specific types of screen-based sedentary activities could be implemented to individuals at high genetic risk of T2D for primary prevention of ASCVD.</p>
16 Keywords
- Aged
- Atherosclerosis
- Diabetes Mellitus, Type 2
- Female
- Genetic Predisposition to Disease
- Heart Disease Risk Factors
- Humans
- Incidence
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Sedentary Behavior
- Television
- Time Factors
- United Kingdom
11 Authors
- Mengyao Wang
- Paul James Collings
- Felix R. Day
- Ken K. Ong
- Soren Brage
- Stephen J. Sharp
- Haeyoon Jang
- Siyeon Suh
- Shan Luo
- Shiu Lun Au Yeung
- Youngwon Kim
1 Application
| Application ID | Title |
|---|---|
| 43528 | Exploring the relationships of movement behaviours with adverse health outcomes. |
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