| Title: | Exploring the application of deep learning methods for polygenic risk score estimation |
| Journal: | Biomedical Physics & Engineering Express |
| Published: | 13 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40020248/ |
| DOI: | https://doi.org/10.1088/2057-1976/adbb71 |
Publication 15598
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Abstract
Background. Polygenic risk scores (PRS) summarise genetic information into a single number with clinical and research uses. Deep learning (DL) has revolutionised multiple fields, however, the impact of DL on PRSs has been less significant. We explore how DL can improve the generation of PRSs.Methods. We train DL models on known PRSs using UK Biobank data. We explore whether the models can recreate human programmed PRSs, including using a single model to generate multiple PRSs, and DL difficulties in PRS generation. We investigate how DL can compensate for missing data and constraints on performance.Results. We demonstrate almost perfect generation of multiple PRSs with little loss of performance with reduced quantity of training data. For an example set of missing SNPs the DL model produces predictions that enable separation of cases from population samples with an area under the receiver operating characteristic curve of 0.847 (95% CI: 0.828-0.864) compared to 0.798 (95% CI: 0.779-0.818) for the PRS.Conclusions. DL can accurately generate PRSs, including with one model for multiple PRSs. The models are transferable and have high longevity. With certain missing SNPs the DL models can improve on PRS generation; further improvements would likely require additional input data.</p>
10 Keywords
- Deep Learning
- Genetic Predisposition to Disease
- Genetic Risk Score
- Genome-Wide Association Study
- Humans
- Models, Genetic
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- ROC Curve
- Risk Factors
3 Authors
- Steven Squires
- Michael N Weedon
- Richard A Oram
1 Application
| Application ID | Title |
|---|---|
| 9072 | The Genetics of anthropometric traits ? Height, weight, BMI and waist circumference |
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