| Title: | Association between the inflammatory potential of diet and chronic renal failure: A cohort study of 163 433 UK Biobank participants |
| Journal: | Nutrition |
| Published: | 15 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40359652/ |
| DOI: | https://doi.org/10.1016/j.nut.2025.112766 |
Publication 15585
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Abstract
OBJECTIVES: There is some preclinical evidence suggesting a pro-inflammatory diet reduces kidney function. In the present study, we aimed to investigate the association of inflammatory potential of diet with the risk of chronic renal failure (CRF).</p>
METHODS: Cox regression models were used to examine the association between the energy-adjusted dietary inflammation index (E-DII) quartiles and CRF adjusting varying degrees of confounders. Restricted cubic spline regression was additionally adopted to determine the association of the continuous E-DII and CRF risk. A series of sensitivity and subgroup analyses were also conducted.</p>
RESULTS: A total of 163,433 participants entered the primary analysis. During a mean follow-up period of 12.65 years, incident CRF occurred in 5, 333 participants (3.26%). The E-DII scores was stratified into four quartile groups. In a fully adjusted multivariable model, the adjusted hazard ratio for the second, third, and highest quartiles of E-DII intake was 1.12 (95% confidence interval [CI]: 1.04-1.21), 1.21 (95% CI: 1.12-1.31), and 1.23 (95% CI: 1.14-1.33), respectively, compared with the lowest quartile. Trend test indicated a statistically significant increasing trend with increasing E-DII quartiles (P < 0.0001). Similarly, restricted cubic spline regression displayed a positive association of continuous E-DII with CRF, wherein higher scores were linked to an elevated risk of CRF. Results of sensitivity analyses demonstrated consistent findings.</p>
CONCLUSIONS: Diet with higher proinflammatory potential was linked to an increased risk of CRF. Implementing measures to limit the intake of pro-inflammatory foods or promoting the adoption of an anti-inflammatory dietary pattern could potentially reduce the occurrence of CRF.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cohort Studies
- Diet
- Female
- Humans
- Inflammation
- Kidney Failure, Chronic
- Male
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- UK Biobank
- United Kingdom
7 Authors
- Yinghong Zhai
- Fangyuan Hu
- Lei Yuan
- Yang Cao
- Xiaofei Ye
- Chao Xue
- Feng Xu
1 Application
| Application ID | Title |
|---|---|
| 99709 | Risk factor and causal association detection in common diseases |
Enabling scientific discoveries that improve human health