| Title: | Association of chronic musculoskeletal pain, APOE Ɛ4 genotype, and analgesics with the risk of dementia: a population-based prospective cohort study |
| Journal: | International Journal of Surgery |
| Published: | 18 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40101131/ |
| DOI: | https://doi.org/10.1097/js9.0000000000002348 |
Publication 15570
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Abstract
Chronic musculoskeletal pain (CMP) is associated with the risk of dementia, yet little is known about whether this association is modified by APOE genotype and whether analgesics may mitigate the risk effect of CMP on dementia. This prospective cohort study, included 415 072 participants from UK Biobank, found that CMP was associated with a higher risk of dementia, and this association may be modified by the APOE genotype. Analgesics may not mitigate the risk effect of CMP on dementia.</p>
14 Keywords
- Aged
- Analgesics
- Apolipoprotein E4
- Chronic Pain
- Dementia
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Musculoskeletal Pain
- Prospective Studies
- Risk Factors
- United Kingdom
4 Authors
- Yuan Zhang
- Jiangtao Feng
- Hongxi Yang
- Shu Li
1 Application
| Application ID | Title |
|---|---|
| 83974 | A framework for analyzing associations and interactions of genetic and non-genetic risk factors toward complex disease outcomes |
Enabling scientific discoveries that improve human health