| Title: | Association of birthweight with all-cause and cause-specific premature mortality in the UK: A prospective cohort study |
| Journal: | Annals of Epidemiology |
| Published: | 21 Mar 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40122321/ |
| DOI: | https://doi.org/10.1016/j.annepidem.2025.03.010 |
Publication 15545
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Abstract
PURPOSE: We investigated the association between birthweight and all-cause and cause-specific premature mortality, and evaluated the effect modification by lifestyle factors.</p>
METHODS: This prospective cohort study used data of participants aged 39-71 years from the UK Biobank in 2006-2010 and followed up till the end of 2022. Birthweight was classified into < 1.0 kg, 1.0-<1.5 kg, 1.5-<2.5 kg, 2.5-<4.0 kg, and ≥ 4.0 kg. Cox proportional-hazards models were used to estimate adjusted hazard ratios (aHR) and 95 % confidence intervals (CI) for premature mortality.</p>
RESULTS: Of 221 848 participants, there were 6336 premature deaths (2148 cardiovascular, 624 respiratory, 3040 cancers, 524 other causes). Birthweight was nonlinearly associated with risks of all-cause, cardiovascular, and cancer-related mortality but the association was linear for respiratory and other-cause mortality. Compared to birthweight of 2.5-<4.0 kg, birthweight< 1.0 kg (aHR 1.36, 95 %CI 1.00-1.85) and ≥ 4.0 kg (1.10, 1.02-1.17) were associated with increased risks of all-cause mortality. A similar pattern was observed for cardiovascular mortality, with corresponding aHRs of 1.54 (1.02-2.49) and 1.16 (1.03-1.31) for birthweight of 2.5-<4.0 kg, and ≥ 4.0 kg, respectively. Birthweight≥ 4.0 kg was associated with increased risk of cancer-related mortality (1.11, 1.00-1.22). The mortality risks did not differ significantly across lifestyle scores (all P-interaction>0.05).</p>
CONCLUSIONS: Both lower and higher birthweight were associated with increased risks of premature mortality from all causes and cardiovascular diseases, and higher birthweight was associated with increased risk of cancer-related mortality.</p>
6 Authors
- Shaohua Yin
- Dan Li
- Yingying Yang
- Qin Wang
- Lei Yuan
- Keyi Si
1 Application
| Application ID | Title |
|---|---|
| 99709 | Risk factor and causal association detection in common diseases |
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