| Title: | Dietary inflammatory potential, genetic predisposition, and incidence of Crohn's disease and ulcerative colitis |
| Journal: | Nutrition & Metabolism |
| Published: | 1 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40312362/ |
| DOI: | https://doi.org/10.1186/s12986-025-00934-z |
| URL: | https://nutritionandmetabolism.biomedcentral.com/counter/pdf/10.1186/s12986-025-00934-z |
Publication 15528
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Abstract
BackgroundEvidence for a potential link between dietary inflammatory potential and inflammatory bowel disease is limited, and the moderating role of genetic susceptibility remains to be assessed.ObjectiveTo evaluate energy-adjusted dietary inflammatory index (E-DII) for the associations with incident Crohn's disease (CD) and ulcerative colitis (UC) and the role of genetic susceptibility.MethodsA total of 205,706 UK Biobank participants who were aged 39-72 years and had no known CD or UC at baseline (2006-2010) were included. The E-DII score was calculated based on energy-adjusted average intakes of 33 food or nutrient items derived from up to five 24-hour dietary recalls. Multivariable Cox regression models were used estimate hazard ratios (HRs) with 95% confidence interval (CI) for incident CD and UC.ResultsDuring a median 12.3 years of follow-up, 382 incident CD and 798 incident UC cases were ascertained. A higher E-DII score was not associated with risk of CD (HR Q4 VS. Q1 = 1.28, 95% CI: 0.94-1.74; P-trend = 0.09) or UC (HR Q4 VS. Q1 = 1.10, 95% CI: 0.90-1.36; P-trend = 0.17). There was an interaction between the E-DII and the polygenic risk score (PRS) for CD on incident CD (P-interaction = 0.023), with an association only among participants with a high PRS (HR Q4 VS. Q1 = 1.64, 95% CI: 1.03-2.61) (P-interaction = 0.023). As compared with the participants with a low PRS for CD and a low E-DII score, participants with high levels of both scores had a particularly higher risk of CD (HR = 3.12; 95% CI: 1.74-5.60).ConclusionsThe association of dietary inflammatory potential with incident CD appears to be amplified by high genetic susceptibility to CD.</p>
8 Authors
- Ji-Mei Gu
- Miao Zhao
- Jie Zhu
- Hao-Wei Tao
- Xiao-Ping Shao
- Li-Qiang Qin
- Yang-Yang Ge
- Guo-Chong Chen
1 Application
| Application ID | Title |
|---|---|
| 90087 | Role of environmental and host factors and their interplays in the development and progression of chronic diseases |
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