| Title: | Mobile phone use characteristics, genetic predisposition and the risk of Parkinson's disease: a prospective cohort study |
| Journal: | Age and Ageing |
| Published: | 3 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40434178/ |
| DOI: | https://doi.org/10.1093/ageing/afaf143 |
Publication 15519
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
We investigated the association between mobile phone use characteristics and Parkinson's disease (PD) risk and whether genetic predisposition modified these associations, utilising data from the UK Biobank. Participants using mobile phones for at least one hour weekly had a lower risk of PD compared to those using less than five minutes weekly (HR: 0.75, 95% CI: 0.65-0.87). Long-term users of mobile phones over eight years had an 18% reduced risk compared to participants with a length of mobile phone use ≤1 year (HR: 0.82, 95% CI: 0.68-1.00), and increased frequency of mobile phone use over two years was associated with a 12% lower risk than those who did not change (HR: 0.88, 95% CI: 0.79-0.98). No interaction between mobile phone use characteristics and PD-PRS was detected. Total brain volume, grey matter and white matter were positively associated with mobile phone use, while white matter hyperintensity was negatively associated.</p>
14 Keywords
- Aged
- Cell Phone
- Cell Phone Use
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Parkinson Disease
- Prospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- United Kingdom
10 Authors
- Juanjuan Zhang
- Junjie Zou
- Yuerong He
- Jiale Shen
- Kunjuan Jing
- Ruiqi An
- Zhen Wang
- Xiaoyan Yao
- Chao Ren
- Yang Xia
1 Application
| Application ID | Title |
|---|---|
| 63454 | Understand the relationship between diet, lifestyle and gene-environment interactions and healthy aging |
Enabling scientific discoveries that improve human health