| Title: | Exploring associations between dual sensory impairment and neuropsychiatric disorders: Insights from a prospective cohort study in the UK Biobank |
| Journal: | Archives of Gerontology and Geriatrics |
| Published: | 18 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40305975/ |
| DOI: | https://doi.org/10.1016/j.archger.2025.105865 |
Publication 15479
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Abstract
BACKGROUND: Evidence of dual sensory impairment (DSI) characterized by comorbid hearing impairment (HI) and visual impairment (VI) is limited in neuropsychiatric disorders. Moreover, the underlying mechanisms remain elusive.</p>
METHODS: Using data from 169,165 UK Biobank participants, we compared cognition and mental health across the no sensory impairment, HI, VI, and DSI groups and investigated the association between the number of sensory impairments and neuropsychiatric disorders in longitudinal COX analyses. We also analyzed the associations of sensory function and its interaction with brain structure, functional connectivity, inflammatory markers, and metabolites and explored their mediating roles.</p>
RESULTS: DSI participants exhibited poor cognition and mental health, and had a higher risk of neuropsychiatric disorders compared to those with HI/VI alone. Both HI and VI were linked to atrophic changes in the hippocampus, thalamus, precuneus, parietal cortex, middle temporal gyrus, etc., and reduced white matter integrity. Brain regions associated with HI and VI exhibited decreased functional connectivity with other cortexes. Hearing and visual performance exhibit a significant interaction in relation to cognitive function, mental health, and metabolites. Brain structures, inflammation, and metabolic biomarkers significantly associated with HI and VI mediated the relationship between sensory impairments and cognition/mental health.</p>
CONCLUSION: Compared to HI/VI alone, DSI is associated with poorer cognitive function, mental health, and a higher risk of neuropsychiatric disorders, potentially driven by the interaction between HI and VI. Additionally, HI and VI are linked to brain atrophy, reduced white matter integrity, and altered functional connectivity. Furthermore, brain structure, inflammation, and metabolic biomarkers mediate the relationship between sensory impairments and cognition/mental health.</p>
17 Keywords
- Aged
- Biological Specimen Banks
- Brain
- Cognition
- Comorbidity
- Female
- Hearing Loss
- Humans
- Magnetic Resonance Imaging
- Male
- Mental Disorders
- Mental Health
- Middle Aged
- Prospective Studies
- UK Biobank
- United Kingdom
- Vision Disorders
11 Authors
- Hai-Hua Guo
- Wei Zhang
- Shuang-Ling Han
- Ya-Nan Ou
- Yan Fu
- Pei-Yang Gao
- Qiong-Yao Li
- Hao-Chen Chi
- Wei Xu
- Lan Tan
- Hui-Fu Wang
1 Application
| Application ID | Title |
|---|---|
| 108930 | Roles of gene-environment interaction in development of Alzheimer's disease: implications in prediction, prevention, and pathogenesis |
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