| Title: | Association between frailty and the progression trajectories of stroke and dementia comorbidity: insights from observational and genetic analyses |
| Journal: | Archives of Gerontology and Geriatrics |
| Published: | 21 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40262338/ |
| DOI: | https://doi.org/10.1016/j.archger.2025.105862 |
Publication 15469
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The relationship between frailty and the progression trajectories of stroke-dementia comorbidity remains inconclusive. This study aimed to determine whether there are associations between frailty and the progression trajectories of stroke-dementia comorbidity, including the transitions from enrollment to incident stroke/dementia, progression to stroke-dementia comorbidity, and ultimately to mortality.</p>
METHODS: This prospective study was conducted based on the UK Biobank cohort. Frailty was assessed using the frailty index (FI) and categorized as robust (FI ≤ 0.10), prefrail (0.10 < FI ≤ 0.25), or frail (FI > 0.25). We used multi-state models and one-sample Mendelian randomization (MR) to investigate the relationships between frailty and the progression trajectories of stroke-dementia comorbidity. Population attributable fraction (PAF) analyses were conducted to assess the attributable risks of frailty and its components.</p>
RESULTS: The final analysis included 459,924 participants. In comparison to the robust, the frail group significantly elevated the risk of transitioning from enrollment to stroke [HR(95 %CI): 2.32(2.19-2.45)], from enrollment to dementia [2.56(2.31-2.83)], from enrollment to mortality [2.32(2.23-2.42)], from stroke to stroke-dementia comorbidity [1.59(1.23-2.05)], from dementia to stroke-dementia comorbidity [1.79(1.29-2.48)], and from stroke to mortality [1.25(1.11-1.40)]. MR analyses revealed that genetically predicted FI was causally associated with higher risks of stroke-dementia comorbidity. PAF analyses indicated that hypertension, diabetes, lung disease, and visual impairment were significant contributors to the risk of progression to stroke-dementia comorbidity.</p>
CONCLUSION: Our findings revealed that frailty status increases the risk of post-stroke dementia, offering important insights for the clinical management and public health strategies.</p>
15 Keywords
- Aged
- Aged, 80 and over
- Comorbidity
- Dementia
- Disease Progression
- Female
- Frail Elderly
- Frailty
- Humans
- Male
- Mendelian Randomization Analysis
- Prospective Studies
- Risk Factors
- Stroke
- United Kingdom
5 Authors
- Dongze Chen
- Yali Zhang
- Zhiqiang Ji
- Yi Zhou
- Zhisheng Liang
1 Application
| Application ID | Title |
|---|---|
| 66137 | Polygeny and pleiotropy among quantitative traits, diseases of circulatory system, respiratory system, and mental disorders. |
Enabling scientific discoveries that improve human health