| Title: | Assessing the impact of gout on cancer risk and the role of healthy lifestyles |
| Journal: | Frontiers in Oncology |
| Published: | 28 Apr 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40356762/ |
| DOI: | https://doi.org/10.3389/fonc.2025.1557175 |
| URL: | https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1557175/pdf |
Publication 15460
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Abstract
Background: Conflicting evidence exists on the link between gout and cancer risk, with limited clarity on the impact of healthy lifestyle factors.</p>
Methods: In the UK Biobank, 7,169 gout patients were matched with 21,507 non-gout controls (1:3 ratio) using propensity scores. Cox regression models assessed cancer risk associated with gout. Among 6,105 gout patients, cancer risk was further evaluated using an eight-factor Healthy Lifestyle Score (HLS) and a weighted HLS.</p>
Results: Gout was linked to a higher cancer incidence [HR (95% CI) = 1.075 (1.013-1.140)]. High HLS in gout patients correlated with a lower cancer risk [HR (95% CI) = 0.825 (0.717-0.948)], with the strongest protective effect observed in those aged ≥60. Sensitivity analyses confirmed these findings.</p>
Conclusion: Gout patients have a higher risk of developing cancer, but a healthy lifestyle, particularly in those aged 60 and older, significantly reduces this risk. These findings highlight the importance of lifestyle interventions for cancer prevention in patients with gout.</p>
7 Authors
- Wenru Shi
- Jie Zhang
- Sitong Wei
- Xiang Wang
- Hongfei Cao
- Dongqing Ye
- Xinyu Fang
1 Application
| Application ID | Title |
|---|---|
| 62663 | Evaluation of causal risk factors for autoimmune diseases: evidence from epidemiological studies, phenome-wide Mendelian randomisation study |
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