| Title: | The interplay between systemic inflammation and myopia: A bidirectional Mendelian randomization and experimental validation study |
| Journal: | International Immunopharmacology |
| Published: | 5 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40327989/ |
| DOI: | https://doi.org/10.1016/j.intimp.2025.114803 |
Publication 15433
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Abstract
PURPOSE: Though the pathogenesis of myopia remains unclear, emerging evidence suggests a potential link between the onset of myopia and systemic inflammation. This study aims to elucidate the causal relationships between the two via Mendelian randomization (MR).</p>
METHODS: We utilized genome-wide association study data on circulating inflammatory proteins (n = 14,824), immune cell traits (n = 3757), and myopia (n cases = 4106, n controls = 394,028) for a standard two-sample bidirectional MR analysis, followed by sensitivity analyses employing diverse approaches. The validation of seven inflammatory molecules was conducted through ELISA analysis of 116 plasma samples from a hospital-based cohort, as well as proteomics data from 3310 participants in the UK Biobank cohort.</p>
RESULTS: Our analysis identified three inflammatory proteins (CXCL9, CXCL11, and T cell surface glycoprotein CD5) and six immune phenotypes, primarily related to T cells, as risk factors for myopia, and IL-5 and eight traits as protective factors. Meanwhile, we observed that myopia may elevate the levels of two inflammatory agents (TNFRSF9 and IL-24) and 12 peripheral immunophenotypes, predominantly associated with T cells and monocytes. Validation analysis in two independent cohorts further corroborated the proinflammatory state in highly myopic patients manifested by significantly elevated plasma levels of CXCL9, CXCL11, and TNFRSF9.</p>
CONCLUSIONS: Our study identified a potential bidirectional causal relationship between systemic immune dynamics and myopia, underscoring the importance of considering myopia in the context of systemic condition. Research is warranted to further identify underlying mechanisms.</p>
12 Keywords
- Adult
- Chemokine CXCL11
- Chemokine CXCL9
- Female
- Genome-Wide Association Study
- Humans
- Inflammation
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Myopia
- Polymorphism, Single Nucleotide
7 Authors
- Zhiqian Huang
- Jitong Zhou
- Shuyu Liu
- Ye Zhang
- Jiaqi Meng
- Xiangjia Zhu
- Yu Du
1 Application
| Application ID | Title |
|---|---|
| 93118 | Associations of lifestyle risk factors, ocular diseases, and mental disorders. |
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