| Title: | Socioeconomic area deprivation and its relationship with dementia, Parkinson's Disease and all-cause mortality among UK older adults: a multistate modeling approach |
| Journal: | Social Science & Medicine |
| Published: | 7 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40388863/ |
| DOI: | https://doi.org/10.1016/j.socscimed.2025.118137 |
Publication 15414
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Abstract
The study analyzed the association of area-level socioeconomic status (SES) with the risk of all-cause dementia, Parkinson's Disease (PD), and all-cause mortality using a multistate approach. Data from the UK Biobank were used (N = 363,663 50+y individuals, ≤15y follow-up), and Cox proportional hazards and multistate parametric models including Weibull regression were conducted, while cardiovascular health was tested as a potential mediator. In multistate models, socioeconomic area-level deprivation, measured by the Townsend Deprivation Index (TDI) z-score, was positively associated with the hazard of going from healthy into the 3 states of PD, dementia, and all-cause mortality (i.e. transitions 1: HR = 1.06, 95 % CI:1.02-1.10, P = 0.005, 2: HR = 1.19, 95 % CI: 1.16-1.22, P < 0.001 and 3: HR = 1.19, 95 % CI: 1.18-1.21, P < 0.001), with no association detected for transitions 4 (PD→Dementia), 5 (PD→Death), or 6 (Dementia→Death). Cardiovascular health did not mediate these associations. Socioeconomic area-level deprivation was directly associated with reduced survival rates from Healthy into Dementia, PD and Death.</p>
14 Keywords
- Aged
- Aged, 80 and over
- Cause of Death
- Dementia
- Female
- Humans
- Male
- Middle Aged
- Mortality
- Parkinson Disease
- Proportional Hazards Models
- Social Class
- Socioeconomic Factors
- United Kingdom
9 Authors
- May A Beydoun
- Michael F Georgescu
- Jordan Weiss
- Nicole Noren Hooten
- Hind A Beydoun
- Jack Tsai
- Christian A Maino Vieytes
- Michele K Evans
- Alan B Zonderman
1 Application
| Application ID | Title |
|---|---|
| 77963 | Dissecting racial/ethnic disparities in dementia traits through socio-economic, lifestyle, cardio-metabolic risk and infectious agents, with focus on Helicobacter pylori sero-positivity |
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