| Title: | New-onset mental disorders increase among patients with metabolic diseases after the COVID-19 pandemic |
| Journal: | Scientific Reports |
| Published: | 8 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40341227/ |
| DOI: | https://doi.org/10.1038/s41598-025-99280-6 |
| URL: | https://www.nature.com/articles/s41598-025-99280-6.pdf |
Publication 15406
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Abstract
There is limited information on new-onset mental disorders in adults with metabolic diseases following the COVID-19 pandemic. Here, we aimed to examine the changes in mental health following the COVID-19 pandemic and identify factors associated with the development of new-onset mental disorders. Among 90,580 UK Biobank participants diagnosed with COVID-19 between Jan 31, 2020 and Oct 31, 2022, those who completed both baseline and follow-up mental health questionnaires in 2016-2017 and 2022-2023 were included in the analysis. New-onset depression, anxiety, and alcohol use disorder following the COVID-19 pandemic, as well as changes in mental health scores, were assessed. Furthermore, their association with sociodemographic, clinical, and self-perceived emotional state-related exposures was examined. Prevalent metabolic diseases were significantly associated with a higher risk of new-onset depression (hypertension: odds ratio [OR], 1.22; 95% CI 1.01-1.47; diabetes: OR 1.8; 95% CI 1.25-2.6; obesity: OR 1.66; 95% CI 1.43-1.95) and anxiety (hypertension: OR 1.32; 95% CI 1.06-1.63; diabetes: OR 1.66; 95% CI 1.06-2.62; obesity: OR 1.2; 95% CI 0.99-1.44) following COVID-19 pandemic. There was a significant increase of Patient Health Questionnaire-9 (PHQ-9; beta, 0.32; 95% CI 0.29-0.35) and Generalized Anxiety Disorder-7 (GAD-7; beta, 0.10; 95% CI 0.06-0.13) scores throughout the COVID-19 pandemic, while Alcohol Use Disorder Identification Test (AUDIT) score decreased over time (beta, − 0.24; 95% CI − 0.30 to − 0.18). Preexisting metabolic diseases were associated with the accelerated increase in the PHQ-9 and GAD-7 scores following the pandemic. Adults with metabolic diseases are associated with an increased risk of new-onset depression, anxiety, and alcohol use disorders following the COVID-19 pandemic.</p>
16 Keywords
- Adult
- Aged
- Anxiety
- COVID-19
- Depression
- Female
- Humans
- Male
- Mental Disorders
- Metabolic Diseases
- Middle Aged
- Pandemics
- Risk Factors
- SARS-CoV-2
- Surveys and Questionnaires
- United Kingdom
15 Authors
- Jeong Min Cho
- Jae-ik Oh
- Jung Hun Koh
- Minsang Kim
- Seung Geun Kim
- Semin Cho
- Soojin Lee
- Yaerim Kim
- Yong Chul Kim
- Seung Seok Han
- Hajeong Lee
- Kwon-Wook Joo
- Yon Su Kim
- Dong Ki Kim
- Sehoon Park
1 Application
| Application ID | Title |
|---|---|
| 53799 | Impact of genetic and environmental factors on the health-related outcomes in chronic kidney disease patients |
Enabling scientific discoveries that improve human health