| Title: | Associations of serum 25-hydroxyvitamin D concentrations with risks of mortality and cardiovascular disease among individuals with psoriasis |
| Journal: | Journal of the American Academy of Dermatology |
| Published: | 14 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40378890/ |
| DOI: | https://doi.org/10.1016/j.jaad.2025.05.1380 |
Publication 15374
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Abstract
BACKGROUND: Evidence remains scarce regarding the relationship between serum 25-hydroxyvitamin D (25(OH)D) and the risk of mortality and cardiovascular disease (CVD) in psoriasis.</p>
OBJECTIVE: To explore the potential protective effect of serum 25(OH)D on the risk of mortality and CVD among patients with psoriasis.</p>
METHODS: This cohort study included 8947 psoriasis patients and 178,937 controls identified at baseline in the UK Biobank cohort. Serum 25(OH)D levels were prospectively collected at the time of recruitment. Multivariable-adjusted Cox proportional hazards regression models were used to evaluate the associations between levels of serum 25(OH)D and risk of overall mortality and CVD incidence.</p>
RESULTS: Compared to the lowest level of serum 25(OH)D (<25 nmol/L), hazard ratios were 0.54 and 0.78 for overall mortality and incident CVD for the highest level of serum 25(OH)D (≥50 nmol/L) among psoriasis patients, respectively (all P < .05). Psoriasis patients with serum 25(OH)D ≥ 50 nmol/L appeared to have no excess risk of mortality and CVD incidence, compared with matched controls.</p>
LIMITATIONS: Information on psoriasis subtypes was not available.</p>
CONCLUSION: A higher level of serum 25(OH)D was associated with a reduced risk of overall mortality and CVD in individuals with psoriasis.</p>
16 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Case-Control Studies
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Psoriasis
- Risk Assessment
- Risk Factors
- United Kingdom
- Vitamin D
8 Authors
- Kaiqing Lin
- Ya Miao
- Lu Gan
- Bin Zhao
- Fang Fang
- Ru Wang
- Xiang Chen
- Jiaqi Huang
1 Application
| Application ID | Title |
|---|---|
| 98583 | Associations of environmental and metabolic risk factors, and the interactions with genetic susceptibility loci with Risk of COVID-19, Chronic Disease and Mortality |
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