| Title: | Inflammatory bowel disease, age of its onset and incident psychiatric disorders: The role of post-IBD lifestyle and medications |
| Journal: | Journal of Affective Disorders |
| Published: | 17 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40389176/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.119420 |
Publication 15367
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Abstract
BACKGROUND: Individuals with inflammatory bowel disease (IBD) are at an increased risk to developing psychiatric disorders (PDs). However, the age of onset patterns for IBD-related PDs and the role of post-IBD lifestyle on the risk of subsequent PDs remain unclear.</p>
METHODS: 394,851 PD-free participants at baseline from the UK Biobank were included, of which 4408 individuals had a history of IBD (2851 ulcerative colitis [UC] and 1200 Crohn's disease [CD]). A combined lifestyle score was constructed and classified into three categories. Cox regression models were applied to evaluate the associations of age of IBD onset and lifestyle categories with PDs risk.</p>
RESULTS: Over a median follow-up of 13.6 years, 56,392 participants were diagnosed with PDs. Participants with IBD had a higher risk of psychiatric morbidity [IBD: hazard ratio (HR):1.20, 95 % confidence interval (CI): 1.11-1.29; UC: HR: 1.21, 95 % CI: 1.11-1.33; CD: HR: 1.15, 95 % CI: 1.01-1.31] compared to non-IBD participants. The risk of PDs increased with advancing age of IBD onset [≤40 years, HR: 1.16, 95 % CI: 1.05-1.29; 40-50 years, HR: 1.19, 95 % CI: 1.02-1.39; >50 years, HR: 1.26, 95 % CI: 1.11-1.42]. Subgroup analysis showed that IBD patients receiving medications did not exhibit an elevated risk of PDs, irrespective of age of onset. Additionally, adherence to a favorable lifestyle significantly reduced the risk of PDs among IBD patients (HR: 0.53, 95 % CI: 0.42-0.67).</p>
CONCLUSION: Individuals with later-onset IBD are more vulnerable to develop any PDs than younger, but adherence to a favorable post-IBD lifestyle and medications may protect against PDs.</p>
16 Keywords
- Adult
- Age of Onset
- Aged
- Colitis, Ulcerative
- Crohn Disease
- Female
- Humans
- Incidence
- Inflammatory Bowel Diseases
- Life Style
- Male
- Mental Disorders
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- United Kingdom
10 Authors
- Ke Liu
- Weiqiong Jin
- Zhihao Ying
- Jiayao Fan
- Xiaole Sheng
- Changling Tang
- Dan Zhou
- Jing Guo
- Guangdi Chen
- Rongpan Bai
1 Application
| Application ID | Title |
|---|---|
| 102158 | Causal gene mapping for complex traits by leveraging genomics and proteomics data |
Enabling scientific discoveries that improve human health