| Title: | Analgesics use and risk of pancreatitis: Result from the UK Biobank |
| Journal: | Clinics and Research in Hepatology and Gastroenterology |
| Published: | 20 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40403927/ |
| DOI: | https://doi.org/10.1016/j.clinre.2025.102616 |
Publication 15291
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Abstract
BACKGROUND: Pancreatitis, an inflammatory pancreatic disorder, arises from various etiologies including alcohol, tobacco, and drug use. Although the initiation of pancreatitis has been strongly linked to several medications, the association between analgesic use and pancreatitis risk remains ambiguous in population-based studies.</p>
METHODS: This prospective cohort study involved 324,982 participants from the UK Biobank. Multivariable-adjusted Cox proportional hazards models were conducted to evaluate the longitudinal association between incident pancreatitis risk and analgesics use, encompassing opioids, non-steroidal anti-inflammatory drugs (NSAIDs), paracetamol, antimigraine preparations, and the mix. Subgroup and sensitivity analyses were conducted to assess the potential effects of baseline factors.</p>
RESULTS: Over a median follow-up of 13.70 years, 2303 cases of pancreatitis were identified. In the fully adjusted model, analgesics utilization increased the risk of pancreatitis (HR 1.13, 95 % CI 1.04-1.23), acute pancreatitis (AP) (HR 1.11, 95 % CI 1.01-1.22), and chronic pancreatitis (CP) (HR 1.25, 95 % CI 1.00-1.56) (All the above p < 0.05). Furthermore, participants who used opioids presented the highest risk of pancreatitis (HR 1.85, 95 % CI 1.49-2.31, p < 0.001), and the mixed group (HR 1.35, 95 % CI 1.21-1.51, p < 0.001) followed. Compared to the non-analgesics group, the risk of both AP and CP also increased in the opioids and the mixed group. Subgroup analysis indicated that the impact of analgesics utilization on the pancreatitis risk may vary with certain covariates, such as age, cholelithiasis, etc. (p-interaction <0.05).</p>
CONCLUSION: In this large population-based prospective cohort, analgesics utilization, particularly opioids and mixed analgesics, was linked to an increased risk of pancreatitis.</p>
5 Authors
- Jiayi Wang
- Wanxin Long
- Zehong Qi
- Yangjie Liao
- Jingbo Li
1 Application
| Application ID | Title |
|---|---|
| 103631 | Epidemiologic and genetic risk factors for benign and malignant pancreatic diseases |
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