| Title: | Hormone therapy and oral contraceptives in the risk of knee osteoarthritis: a prospective cohort study |
| Journal: | Menopause The Journal of The North American Menopause Society |
| Published: | 20 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40392235/ |
| DOI: | https://doi.org/10.1097/gme.0000000000002560 |
Publication 15288
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Abstract
OBJECTIVE: To evaluate the association of hormone therapy (HT) and oral contraceptives (OC) with the risk of knee osteoarthritis (KOA).</p>
METHODS: Using data from the UK Biobank, we included 211,345 women (mean 56.5 y) who were free of KOA and had self-reported data on the use of HT and OC at baseline. The outcome was an incident KOA during the follow-up. Cox regression models were used to evaluate the association of the status (never, former, current) and duration of HT and OC use with the risk of KOA. We also assessed the association between specific exogenous sex hormones and the risk of KOA.</p>
RESULTS: During a median follow-up of 13.6 years, 14,878 (7.0%) women developed KOA. Compared with women who had never used HT, both former and current users had an increased risk of KOA [former: hazard ratio (HR)=1.25, 95% CI: 1.20-1.31; current: HR=1.46, 95% CI: 1.35-1.58; Ptrend <0.001). There was a dose-responsive association between the duration of HT use and the risk of KOA (HR=1.20-1.43, Ptrend <0.001). Former use of OC increased KOA risk only in women <60 years (HR=1.15, 95% CI: 1.04-1.27). In addition, both estrogen and progestogen and their combination were associated with an increased risk of KOA (HR=1.33-1.47).</p>
CONCLUSIONS: There is a dose-responsive association between the duration of HT use and the risk of KOA among middle-aged and older women. History of OC use may increase the risk of KOA in women younger than 60 years.</p>
11 Keywords
- Aged
- Contraceptives, Oral
- Estrogen Replacement Therapy
- Female
- Humans
- Middle Aged
- Osteoarthritis, Knee
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- United Kingdom
9 Authors
- Junjie Wang
- Xiaoyue Zhang
- Liru Ge
- Xing Xing
- Xusheng Cheng
- Jianqiao Wang
- Jingyi Yin
- Xianzhe Zhu
- Guoqi Cai
1 Application
| Application ID | Title |
|---|---|
| 96569 | Uncovering the interplay between musculoskeletal diseases and cardiometabolic and cognitive health |
Enabling scientific discoveries that improve human health