| Title: | Anatomical heterogeneity in low-grade and high-grade gliomas: A multiscale perspective |
| Journal: | NeuroImage |
| Published: | 21 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40409387/ |
| DOI: | https://doi.org/10.1016/j.neuroimage.2025.121289 |
Publication 15277
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Abstract
BACKGROUND: Low-grade gliomas (LGGs) and high-grade gliomas (HGGs) often exhibit distinct spatial distributions, a phenomenon that remains incompletely understood. Based on previous research, we hypothesized that functional networks, neurotransmitters, and isocitrate dehydrogenase-1 (IDH-1) status characterize the spatial patterns of LGG and HGG.</p>
METHODS: We analyzed 399 patients diagnosed with primary gliomas. First, we generated glioma frequency maps based on tumor grade, neurotransmitters, and IDH-1 status and constructed a brain functional connectivity network to explore heterogeneity in glioma location. Second, all tumor masks were mirror-symmetrized onto the brain's left hemisphere to facilitate feature extraction. We performed independent component analysis on merged four-dimensional files using Multivariate Exploratory Linear Optimized Decomposition into Independent Component (MELODIC), identifying four IDH-1 wild-type lesion covariance networks (IDHwt-LCNs) and three IDH-1 mutant lesion covariance networks (IDHmut-LCNs) with distinct spatial distributions, and analyzing correlation between the neurotransmitter levels and the IDH-wt/mut specific LCNs. Finally, we compared 42 white matter fibers extracted using XTRACT with 39 functional brain connectivity networks from the multi-subject dictionary learning (MSDL) atlas, revealing significant associations among the frontal aslant tract (FAT) and the intraparietal sulcus (IPS).</p>
RESULTS: Our findings revealed high anatomical heterogeneity between LGG and HGG. Moreover, the high node strength played a critical role in the distinct spatial distribution of glioma. Significant correlations were observed between glioma frequency maps and dopaminergic, cholinergic, μ-opioid, and serotonergic neurotransmission. Furthermore, IDHwt/mut-LCNs analysis demonstrated that IDH-1 status influences glioma distribution, involving key brain structures. Lastly, we also found significant correlations between IDHwt/mut-LCNs and the neurotransmission of dopaminergic, cholinergic, μ-opioid, and serotonergic systems.</p>
CONCLUSION: Our study highlighted the mechanisms by which functional networks, neurotransmitter systems, and IDH-1 status collectively contribute to the anatomical heterogeneity observed in LGG and HGG.</p>
13 Keywords
- Adult
- Aged
- Brain Neoplasms
- Female
- Glioma
- Humans
- Isocitrate Dehydrogenase
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Neoplasm Grading
- Nerve Net
- Young Adult
5 Authors
- Shengpeng Liang
- Nuo Dong
- Yumin Chen
- Yang Yang
- Haibing Xu
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