| Title: | Hot beverage intake and oesophageal cancer in the UK Biobank: prospective cohort study |
| Journal: | British Journal of Cancer |
| Published: | 19 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39972189/ |
| DOI: | https://doi.org/10.1038/s41416-025-02953-2 |
| URL: | https://www.nature.com/articles/s41416-025-02953-2.pdf |
Publication 15261
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Abstract
BackgroundDrinking maté, a type of tea consumed at a very hot temperature in South America has been considered as a risk factor for oesophageal squamous cell carcinoma (ESCC).MethodsWe assessed daily intake and preferred temperature of hot beverages (tea and coffee) in relation to incident ESCC (n = 242) and adenocarcinoma (EAC; n = 710) among 454,796 adults in the UK Biobank. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards regression.ResultsRelative to non-drinkers and warm temperature drinkers (referent group), drinking 4-6 cups/d (HR, 1.97; 95% CI, 1.14-3.38) or more of hot temperature beverages was associated with higher risk of ESCC; HRs increased with increasing daily intake of hot temperature beverages (P-trend < 0.01). ESCC risk was still higher for those who drank very hot beverages; drinking ≤ 4 cups/d was associated with a 2.5-fold higher risk (HR, 2.52; 95% CI, 1.27-5.03), and risk increased with increasing daily intake of very hot temperature beverages (P-trend < 0.01). There was no clear association for EAC.ConclusionsOur findings provide new evidence that drinking hot or very hot beverages is a risk factor for ESCC in the UK where drinking hot tea and coffee is common.</p>
20 Keywords
- Adenocarcinoma
- Adult
- Aged
- Beverages
- Biological Specimen Banks
- Carcinoma, Squamous Cell
- Coffee
- Esophageal Neoplasms
- Esophageal Squamous Cell Carcinoma
- Female
- Hot Temperature
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Tea
- UK Biobank
- United Kingdom
8 Authors
- Maki Inoue-Choi
- Yesenia Ramirez
- Caitlin O'Connell
- Amy Berrington de Gonzalez
- Sanford M. Dawsey
- Christian C. Abnet
- Neal D. Freedman
- Erikka Loftfield
1 Application
| Application ID | Title |
|---|---|
| 18623 | Potential interactions between coffee consumption, genetic polymorphisms, diabetes, liver and cardiovascular disease, and total and cause-specific mortality |
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