| Title: | Association of Plasma Fatty Acid Profile With Trajectory of Multimorbidity and Mortality: A Community-Based Longitudinal Study |
| Journal: | The Journals of Gerontology Series A |
| Published: | 15 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39954290/ |
| DOI: | https://doi.org/10.1093/gerona/glaf031 |
Publication 15256
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Plasma fatty acids have been linked to various chronic diseases and mortality, but the extent to which fatty acids are associated with the trajectory of multimorbidity remains unclear. We investigated the association of fatty acid profile with multimorbidity trajectories and event-free survival.</p>
METHODS: Within the UK Biobank, 138,685 chronic disease-free participants were followed for up to 16 years. Seventeen plasma fatty acids were measured by nuclear magnetic resonance. A comprehensive healthy fatty acid score (HFAS) was constructed using LASSO regression. Incidence of chronic diseases and death were ascertained through linkages to medical and death records. Event-free survival was defined as survival without chronic diseases or death. Data were analyzed using a linear mixed-effects model, Cox regression, and Laplace regression.</p>
RESULTS: High HFAS was associated with lower risk of chronic diseases/death (hazard ratio [HR]: 0.907, 95% confidence interval [CI]: 0.888-0.925) and prolonged event-free survival time by 0.636 (95% CI: 0.500-0.774) years compared with low HFAS. High HFAS was also associated with a slower accumulation trajectory of multimorbidity (β: -0.042, 95% CI: -0.045 to -0.038). There was a significant multiplicative interaction between moderate-to-high HFAS and healthy lifestyle on chronic disease/death (p for interaction = .002) and multimorbidity accumulation trajectories (p for interaction < .001).</p>
CONCLUSIONS: A healthier plasma fatty acid metabolic profile is associated with a slower accumulation of multimorbidity and prolonged event-free survival time. A healthy lifestyle may strengthen the protective association of HFAS with the risk of chronic diseases/death and the accumulation trajectory of multimorbidity.</p>
11 Keywords
- Aged
- Chronic Disease
- Fatty Acids
- Female
- Humans
- Longitudinal Studies
- Male
- Middle Aged
- Mortality
- Multimorbidity
- United Kingdom
8 Authors
- Yang Li
- Jiao Wang
- Yuyang Miao
- Michelle M Dunk
- Silvia Maioli
- Zhongze Fang
- Qiang Zhang
- Weili Xu
1 Application
| Application ID | Title |
|---|---|
| 67048 | THE BODY-MIND CONNECTION: EXPLORING THE BIOLOGICAL MECHANISMS UNDERLYING THE EFFECTS OF SOMATIC HEALTH ON BRAIN AGING |
Enabling scientific discoveries that improve human health