| Title: | Associations of Grip Strength Asymmetry With Multiple Health Outcomes |
| Journal: | American Journal of Preventive Medicine |
| Published: | 12 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39952446/ |
| DOI: | https://doi.org/10.1016/j.amepre.2025.02.003 |
Publication 15239
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Abstract
INTRODUCTION: The relationships between grip strength asymmetry and cardiovascular, respiratory, and cancer outcomes and all-cause mortality remain unclear.</p>
METHODS: Among 443,132 UK Biobank participants enrolled from 2006 to 2010, grip strength asymmetry was defined as the ratio of left-hand grip strength (kg) to right-hand grip strength (kg) <0.9 or >1.1. The Cox proportional model was employed to assess the associations of grip strength asymmetry with cardiovascular, respiratory, and cancer outcomes and all-cause mortality. Net reclassification improvement was assessed to evaluate the improvement in risk discrimination for outcomes after adding grip strength asymmetry to the model with established office-based risk factors.</p>
RESULTS: After a mean follow-up of 12.1 years, 28,478 (6.4%) deaths occurred. grip strength asymmetry was significantly associated with all-cause (hazard ratio: 1.096; 95% CI=1.070, 1.122), cardiovascular disease (hazard ratio: 1.141; 95% CI=1.071, 1.216), respiratory disease (hazard ratio: 1.183; 95% CI=1.076, 1.301), chronic obstructive pulmonary disease (hazard ratio: 1.284; 95% CI=1.087, 1.516), and cancer (hazard ratio: 1.051; 95% CI=1.017, 1.086) mortality. Significant associations of grip strength asymmetry with cardiovascular disease (hazard ratio: 1.029; 95% CI=1.004, 1.054), respiratory disease (hazard ratio: 1.074; 95% CI=1.051, 1.103), chronic obstructive pulmonary disease (hazard ratio: 1.123; 95% CI=1.038, 1.215), and colorectal cancer (hazard ratio: 1.051; 95% CI=1.037, 1.066) incidence were observed. Moreover, adding grip strength asymmetry to a model with established office-based risk factors significantly improved the ability to predict all-cause, cardiovascular disease, and respiratory disease mortality.</p>
CONCLUSIONS: Grip strength asymmetry was associated with a range of adverse health outcomes and may have clinical use in predicting all-cause, cardiovascular disease, and respiratory disease mortalities. Further studies are warranted to validate the clinical value of the grip strength asymmetry assessment.</p>
13 Keywords
- Aged
- Cardiovascular Diseases
- Female
- Follow-Up Studies
- Hand Strength
- Humans
- Male
- Middle Aged
- Neoplasms
- Proportional Hazards Models
- Respiratory Tract Diseases
- Risk Factors
- United Kingdom
10 Authors
- Wei Liu
- Xuefeng Lai
- Da Shi
- Hao Wang
- Lieyang Fan
- Wendi Shi
- Linling Yu
- Ruyi Liang
- Weihong Chen
- Bin Wang
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
Enabling scientific discoveries that improve human health