| Title: | The health impacts and genetic architecture of food liking in cardio-metabolic diseases |
| Journal: | Nature Communications |
| Published: | 23 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40410146/ |
| DOI: | https://doi.org/10.1038/s41467-025-59945-2 |
| URL: | https://www.nature.com/articles/s41467-025-59945-2.pdf |
Publication 15236
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Abstract
We evaluated temporal and genetic relationships between 176 food-liking-traits and cardio-metabolic diseases using data from the UK Biobank (N = 182,087) for observational analyses and summary-level GWAS data from FinnGen and other consortia (N = 406,565-977,323) for genetic analyses. Integrating observational and genetic results, we identified two detrimental food-liking-traits (bacon and diet-fizzy-drinks) and three protective food-liking-traits (broccoli, pizza, and lentils/beans). These food-liking-traits are associated with habitual food intake and influence cardio-metabolic proteins and biological processes. Notably, we found three genetic links: diet-fizzy-drinks with heart-failure, bacon with type-2-diabetes, and lentils/beans with type-2-diabetes, identifying 54 pleiotropic single-nucleotide-variants, impacting both phenotypes. Our data show the diet-fizzy-drinks and heart-failure link maybe not direct, as diet-fizzy-drinks liking correlates with sweet food consumption and shares variants linked to BMI, adiposity, platelet count and cardio-metabolic traits. The pleiotropic single-nucleotide-variants map to 251 tissue-specific genes, with four showing high druggability potential, highlighting personalized dietary strategies for cardio-metabolic diseases.</p>
14 Keywords
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Diet
- Female
- Food Preferences
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Metabolic Diseases
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
- United Kingdom
16 Authors
- Wenbo Jiang
- Hang Wang
- Yiding Geng
- Meijuan Guo
- Yingdong Zuo
- Sijia Han
- Zijie Liu
- Shuaijun Chen
- Shuzhen Fan
- Shangying Li
- Conghui Qiao
- Qianzhu Li
- Bai Li
- Yunpeng Zhang
- Wei Wei
- Tianshu Han
2 Applications
| Application ID | Title |
|---|---|
| 90232 | Association of risk factors in terms of diet, lifestyle, genetic susceptibility, metabolic disorder and treatment with the comorbidity of diabetes with cancer. |
| 203867 | Risk factors in terms of lifestyle, diet, treatment, genetic susceptibility, plasma metabolites on the incidence and mortality of Cardiovascular disease and related non-cardiac multimorbidity. |
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