| Title: | Accelerated Biological Aging and Longitudinal Progression of Cardiometabolic Disease, Subsequent Dementia, and Death: A Multistate Analysis |
| Journal: | European Journal of Neurology |
| Published: | 28 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40433862/ |
| DOI: | https://doi.org/10.1111/ene.70221 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ene.70221 |
Publication 15201
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Abstract
BACKGROUND: The role of biological age (BA) acceleration in longitudinal disease progression from health to cardiometabolic disease (CMD), then to post-CMD dementia (including vascular dementia (VaD) and Alzheimer's disease (AD)), and finally to death remains unclear.</p>
METHODS: Using data from 284,723 UK Biobank participants, two established BA measures (Klemera-Doubal Method Biological Age [KDM-BA] and PhenoAge) were generated on the basis of baseline clinical biomarkers. Post-CMD dementia was defined as dementia that occurred after the first occurrence of CMD. Multistate analysis was constructed to examine the association between BA accelerations and longitudinal progression of post-CMD dementia. We further explored the role of two BA accelerations in CMD-specific transitions and dementia-specific transitions, respectively.</p>
RESULTS: Over a median follow-up of 13.7 years, 47,150 participants developed CMD, and 999 developed post-CMD dementia. Biologically older participants demonstrated robustly higher risks from healthy to CMD, then to post-CMD dementia, and finally to death. For the transition from baseline to CMD, adjusted HRs (95% CI) were 1.34 (1.32, 1.35) for each SD increase in KDM-BA acceleration and 1.19 (1.18, 1.20) for PhenoAge acceleration. For the transition from CMD to post-CMD dementia, HRs were 1.12 (1.04, 1.20) for KDM-BA acceleration and 1.10 (1.04, 1.17) for PhenoAge acceleration. Both BA accelerations were more strongly associated with the transition from CMD to post-CMD VaD than with the transition to post-CMD AD.</p>
CONCLUSIONS: BA accelerations hold promise for identifying the disease progression of post-CMD dementia in routine clinical practice and slowing down disease progression through the interventions that slow down biological aging.</p>
13 Keywords
- Aged
- Aged, 80 and over
- Aging
- Cardiovascular Diseases
- Dementia
- Disease Progression
- Female
- Humans
- Longitudinal Studies
- Male
- Metabolic Diseases
- Middle Aged
- United Kingdom
10 Authors
- Ning Zhang
- Haojiang Zuo
- Jiajie Cai
- Yi Xiang
- Yuan Zhang
- Hongmei Zhang
- Yifan Hu
- Hao Xu
- Xiong Xiao
- Xing Zhao
1 Application
| Application ID | Title |
|---|---|
| 117185 | Research on risk factors and pathogenesis of aging-related chronic diseases |
Enabling scientific discoveries that improve human health