| Title: | Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study |
| Journal: | European Journal of Nutrition |
| Published: | 28 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40437330/ |
| DOI: | https://doi.org/10.1007/s00394-025-03705-x |
Publication 15199
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Abstract
PurposeWe aim to evaluate the association between the use of glucosamine, a widely used dietary supplement, and the risk of IBD-related surgery in a prospective cohort study.MethodsWe leveraged data from 6059 individuals with IBD from the UK Biobank. Habitual use, frequency of use, and the dose of glucosamine were evaluated using self-reported records, multiple rounds of dietary recall, and prescription information from primary care data, respectively. IBD-related surgery was identified through inpatient data. Cox proportional-hazard model and logistic regression model were applied to examine the associations.ResultsDuring a mean follow-up of 12.2 years, we documented 684 incident IBD-related surgery events. Compared with non-users, habitual glucosamine users presented (66.6 vs 97.1 cases/10,000 person-years, HR 0.73, 95% CI 0.58-0.92, P = 0.009) lowered risk of IBD-related surgery, decreased risk in Crohn's disease (80.6 vs 131.0 cases/10,000 person-years, HR 0.60, 95% CI 0.41-0.89, P = 0.011), while it was not significant in ulcerative colitis (61.1 vs 79.5 cases/10,000 person-years, HR 0.88, 95% CI 0.65-1.18, P = 0.386). The risks of IBD-related surgery were also lower among occasional users (HR 0.34, 95% CI 0.15-0.77, P = 0.010) and constant users (HR 0.48, 95% CI 0.25-0.90, P = 0.022) than non-users. For those using prescribed glucosamine, a higher prescription dose was associated with a lower risk of related surgery (OR 0.15, 95% CI 0.02-0.86, P = 0.034).ConclusionUse of glucosamine, as a safe dietary supplement, is associated with a lower risk of IBD-related surgery, which would be a promising strategy in IBD management.</p>
13 Keywords
- Adult
- Aged
- Colitis, Ulcerative
- Dietary Supplements
- Female
- Glucosamine
- Humans
- Inflammatory Bowel Diseases
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
9 Authors
- Jiawei Geng
- Xuejie Chen
- Sidan Wang
- Lintao Dan
- Qijia Gong
- Jie Chen
- Xiaoyan Wang
- Xiaocang Cao
- Zhongyan Du
1 Application
| Application ID | Title |
|---|---|
| 79612 | Disentangle the interplay between genetic predisposition, social environment, and lifestyle in the development of complex and common aging-related diseases and syndromes |
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