| Title: | Optimal dose and pattern of physical activity to prevent diagnosed depression: prospective cohort study |
| Journal: | Psychological Medicine |
| Published: | 4 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39901870/ |
| DOI: | https://doi.org/10.1017/s003329172400343x |
Publication 15177
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Abstract
BACKGROUND: Little is known about the dose and pattern of moderate-to-vigorous physical activity (MVPA) to prevent depression. We aimed to assess the prospective association of dose and pattern of accelerometer-derived MVPA with the risk of diagnosed depression.</p>
METHODS: We included 74,715 adults aged 40-69 years from the UK Biobank cohort who were free of severe disease at baseline and participated in accelerometer measurements (mean age 55.2 years [SD 7.8]; 58% women). MVPA at baseline was derived through 1-week wrist-worn accelerometry. Diagnosed depression was defined by hospitalization with ICD-10 codes F32.0-F32.A. Restricted cubic splines and Cox regression determined the prospective association of dose and pattern of MVPA with the risk of incident depression.</p>
RESULTS: Over a median 7.9-year follow-up, there were 3,089 (4.1%) incident cases of depression. Higher doses of MVPA were curvilinearly associated with lower depression risk, with the largest minute-per-minute added benefits occurring between 5 (HR 0.99 [95% CI 0.96-0.99]) and 280 (HR 0.67 [95% CI 0.60-0.74]) minutes per week (reference: 0 MVPA minutes).</p>
CONCLUSION: Regardless of pattern, higher doses of MVPA were associated with lower depression risk in a curvilinear manner, with the greatest incremental benefit per minute occurring during the first 4-5 h per week. Optimal benefits occurred around 15 h/week.</p>
11 Keywords
- Accelerometry
- Adult
- Aged
- Depression
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Prospective Studies
- United Kingdom
6 Authors
- Lars Louis Andersen
- Rubén López-Bueno
- Aaron Kandola
- Rodrigo Núñez-Cortés
- Laura López-Bueno
- Joaquín Calatayud
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